In a continuing effort to develop novel β-carbolines endowed with better insecticidal activity, a simple high-yielding method for the synthesis of harmine compounds starting from L-tryptophan has been developed and a series of 1,3-substituted β-carboline derivatives have been synthesized and evaluated for their cytotoxicity against insect cultured Sf9 cell line in vitro and insecticidal activit...

BACKGROUND Leishmaniasis is a major public health problem worldwide. The aim of the present study was to investigate medicinal plants with anti-Leishmania activity which used in Iran. METHODS Data were systematically gathered from five English databases including Ebsco, Science Direct, PubMed, Google Scholar and Scopus, four Persian databases including Magiran, Iran doc, Iran medex and the Sc...

objective: addiction, especially morphine dependence is a prevalence and incurable disease. with regard to low ability of new chemical drugs in treatment of addicted ones and with respect to herbal medicine recommendation due to lower side effects and cheap production. this study experimentally examined the effect of p.harmala on morphine withdrawal syndrome. materials and methods: animals wer...

Medicinal plants are an inexhaustible source of molecules with several biological activities. The main objective this research was the evaluation antimitotic and genotoxic effect by Allium cepa test methanolic extract leaves Peganum harmala, a spontaneous plant from arid zones Algeria (Timzerth, Laghouat). Different concentrations (1, 4, 10, 16 mg∙mL-1) extract, as well two standards (colchicin...

Peganum harmala L. (Zygophyllaceae) known locally as harmel is a medicinal plant. In traditional medicine, its seeds have long been used for therapeutic purposes because of their richness in β-carboline alkaloids. This study aimed to evaluate the maternal and developmental toxicity during pregnancy by daily IP administration 7.99 mg/kg/day (1/20 DL50) total alkaloids extract P.harmala’ seeds. T...