MicroRNAs (miRNAs) play a major role in the post-transcriptional regulation of target genes, especially in development and differentiation. Our understanding about the transcriptional regulation of miRNA genes is limited by inadequate annotation of primary miRNA (pri-miRNA) transcripts. Here, we used CAGE-seq and RNA-seq to provide genome-wide identification of the pri-miRNA core promoter reper...

Comparative effects of partial root-zone irrigation (PRI) and deficit irrigation (DI) on xylem pH, ABA, and ionic concentrations of tomato (Lycopersicon esculentum L.) plants were investigated in two split-root pot experiments. Results showed that PRI plants had similar or significantly higher xylem pH, which was increased by 0.2 units relative to DI plants. Nitrate and total ionic concentratio...

Using loblolly pine, shortleaf pine, white oak, and northern red oak as examples, this paper considers the behavior of potential relative increment (PRI) models of optimal tree diameter growth under data uncertainty. Recommendations on initial sample size and the PRI iterative curve fitting process are provided. Combining different state inventories prior to PRI model development increased samp...

The relationship between the pri-let-7a-1 rs10739971 polymorphism and gastric cancer (GC) risk has been reported. However, the role of this polymorphism in the prognosis of GC remains largely elusive. Sequenom MassARRAY platform method and the polymerase chain reaction (PCR)-restriction fragment length polymorphism were used to investigate pri-let-7a-1 rs10739971 G→A in 334 GC patients. Real-ti...

In previous papers, we presented data on studies on the anticancer activity of the vitamin D₃ analogs, named PRI-2191 and PRI-2205, in different cancer models. In this study, we showed the improved antiproliferative activity of a combination of imatinib mesylate (Gleevec, GV) and cytostatic agents in in vitro studies, when used with a third compound, namely PRI-2191, in an A549 human lung cance...

The Jackson Hole, Wyoming, elk herd lacks an effective “commons institution” for its management. Conflict over management is particularly intense for the segment of the herd that winters in the National Elk Refuge. The fundamental problem is that too many elk are concentrated in too small an area on the refuge in winter, leading to a high incidence of the disease brucellosis, vulnerability to t...

OBJECTIVES Environmental factors associated with winter outdoor falls are poorly understood. This study describes the demographic, spatial and temporal distribution of outdoor falls that occurred in Laval and Montréal Island (Canada) in relation to meteorological conditions. METHOD Data on falls, including geographic coordinates, were obtained from ambulance services (December 1, 2008 to janu...

The evolution of resistance against pesticides is an important problem of modern agriculture. The high-dose/refuge strategy, which divides the landscape into treated and nontreated (refuge) patches, has proven effective at delaying resistance evolution. However, theoretical understanding is still incomplete, especially for combinations of limited dispersal and partially recessive resistance. We...