Several important physiological transactions, including control of replicative life span (RLS), prevention of collision between replication and transcription, and cellular differentiation, require programmed replication fork arrest (PFA). However, a general mechanism of PFA has remained elusive. We previously showed that the Tof1-Csm3 fork protection complex is essential for PFA by antagonizing...

Mass customization is becoming an important agenda in industry and academia alike. This paper deals with mass customization from a product development perspective. A framework of design for mass customization (DFMC) by developing product family architecture (PFA) is presented. To deal with tradeoffs between diversity of customer requirements and reusability of design and process capabilities, D...

Mutants of herpes simplex virus type 1, resistant to phosphonoformate (PFA) and phosphonoacetate (PAA), have been selected in cell culture. The PFAresistant mutant (HSV-PFAr) and the PAA-resistant mutant (HSV-PAAr) were also resistant to PAA and PFA, respectively. This cross-resistance indicates that PFA and PAA interact at the same site. The HSV-PFAr had a decreased susceptibility to vidarabin...

Profunda femoris artery (PFA) pseudoaneurysm after blunt trauma without associated femur fracture is a rare occurrence. Most of the reported cases of PFA pseudoaneurysm in the English literature developed after penetrating trauma, surgical procedures, and femur fractures. We present two such cases following blunt trauma and without any associated long bone injury. After initial imaging failed t...

The vestibular system responds to head acceleration by producing compensatory reflexes in the eyes and postural muscles. In this study, we investigated the effect of brief interaural acceleration on the vestibular evoked myogenic potential (VEMP) in 10 normal subjects and 10 patients with bilateral (bVL) or unilateral vestibular loss (uVL). The stimuli were delivered with a handheld minishaker ...

AIS 1 neck injuries have become the most common injury in vehicle crashes, especially rear impacts. Reserch has shown that there are variations in rear impacts causing initial symptoms and residual disability to the neck. Therefore impacts in which the duration of symtoms di@er need to be separated in analyses. Concerning AIS 1 neck injury, crash severity is usually measured as change of veloci...

IT usage is generally viewed as a key indicator of adoption success and a prerequisite for deriving benefits. Yet, while IT usage can provide a good measure of adoption success, it does not necessarily yield desirable outcomes, i.e., the individual benefits expected by its designers. This paper investigates how IT use leads to its desirable outcomes based on a functional affordance (FA) perspec...

Most severe head injuries in judo are reported as acute subdural hematoma. It is thus necessary to examine the rotational acceleration of the head to clarify the mechanism of head injuries. We determined the rotational acceleration of the head when the subject is thrown by judo techniques. One Japanese male judo expert threw an anthropomorphic test device using two throwing techniques, Osoto-ga...

Models of student performance can incorporate a skill decomposition that lists the skills that each activity requires. A good model must be sensitive to improvements in skill decomposition. We validate the Recent-Performance Factors Analysis model of student performance by checking its sensitivity to the skill decomposition. We use a dataset from a tutoring system where the skill model has been...

This paper presents an effective Polar Format Algorithm (PFA) for spotlight bistatic synthetic aperture radar (SAR) with arbitrary geometry configuration. Nonuniform interpolation and resampling are adopted when converting raw data from polar coordinates to Cartesian coordinates according to the characteristics of raw data samples in spatial frequency space. Thus, the proposed algorithm avoids ...