نتایج جستجو برای: pdgfr β

تعداد نتایج: 178428  

2011
Ze Tian Jie Shen Fengfei Wang Peigen Xiao Junshan Yang Hetian Lei Andrius Kazlauskas Isaac S. Kohane Erxi Wu

Platelet-derived growth factor receptors (PDGFRs) have been implicated in a wide array of human malignancies, including medulloblastoma (MB), the most common brain tumor of childhood. Although significant progress in MB biology and therapeutics has been achieved during the past decades, MB remains a horrible challenge to the physicians and researchers. Therefore, novel inhibitors targeting PDGF...

Journal: :The EMBO journal 2005
Julia Kiyan Roman Kiyan Hermann Haller Inna Dumler

Urokinase (uPA)-induced signaling in human vascular smooth muscle cells (VSMC) elicits important cellular functional responses, such as cell migration and proliferation. However, how intracellular signaling is linked to glycolipid-anchored uPA receptor (uPAR) is unknown. We provide evidence that uPAR activation by uPA induces its association with platelet-derived growth factor receptor (PDGFR)-...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Paul Mathew Peter F Thall Corazon D Bucana William K Oh Michael J Morris Donnah M Jones Marcella M Johnson Sijin Wen Lance C Pagliaro Nizar M Tannir Shi-Ming Tu Anthony A Meluch Lon Smith Lorenzo Cohen Sun-Jin Kim Patricia Troncoso Isaiah J Fidler Christopher J Logothetis

PURPOSE To further assess preclinical and early clinical evidence that imatinib mesylate, a platelet-derived growth factor receptor (PDGFR) inhibitor, modulates taxane activity in prostate cancer and bone metastases, a randomized study was conducted. EXPERIMENTAL DESIGN Men with progressive castration-resistant prostate cancer with bone metastases (n = 144) were planned for equal randomizatio...

Journal: :American journal of respiratory and critical care medicine 2008
Frédéric Perros David Montani Peter Dorfmüller Ingrid Durand-Gasselin Colas Tcherakian Jérôme Le Pavec Michel Mazmanian Elie Fadel Sacha Mussot Olaf Mercier Philippe Hervé Dominique Emilie Saadia Eddahibi Gérald Simonneau Rogério Souza Marc Humbert

RATIONALE Platelet-derived growth factor (PDGF) promotes the proliferation and migration of pulmonary artery smooth muscle cells (PASMCs), and may play a role in the progression of pulmonary arterial hypertension (PAH), a condition characterized by proliferation of PASMCs resulting in the obstruction of small pulmonary arteries. OBJECTIVES To analyze the expression and pathogenic role of PDGF...

Ali Reza Delshad, Hojjat-Allah Abbaszadeh, Majid Saghedi Zadeh, Taher Taheri, Taki Tiraihi,

Background: The present study investigated the functional maturity of oligodendrocyte derived from rat bone marrow stromal cells (BMSC). Methods: The BMSC were isolated from female Sprague-Dawley rats and evaluated for different markers, such as fibronectin, CD106, CD90, Oct-4 and CD45. Transdifferentiation of OLC from BMSC was obtained by exposing the BMSC to DMSO and 1 µM all-trans-retinoic a...

2014
Hee Yeon Kim Chang Wook Kim

After approval of imatinib for treatment of chronic myeloid leukemia, molecular-targeted therapies make change of the management strategies against cancers. Many target molecules have been revealed in several cancers such as lung cancer, breast cancer, colorectal cancer, and hematopoietic tumor. Representative molecular-targeted agents are trastuzumab for breast cancer, imatinib and rituximab f...

2010
Joshua M. Lang Michael R. Harrison

Dramatic advances in the care of patients with advanced renal cell carcinoma have occurred over the last ten years, including insights into the molecular pathogenesis of this disease, that have now been translated into paradigm-changing therapeutic strategies. Elucidating the importance of signaling cascades related to angiogenesis is notable among these achievements. Pazopanib is a novel small...

2017
Cora Stegmann Daniel Hochdorfer Diana Lieber Narmadha Subramanian Dagmar Stöhr Kerstin Laib Sampaio Christian Sinzger

Human cytomegalovirus (HCMV) is a widely distributed herpesvirus that causes significant morbidity in immunocompromised hosts. Inhibitors of viral DNA replication are available, but adverse effects limit their use. Alternative antiviral strategies may include inhibition of entry. We show that soluble derivatives of the platelet-derived growth factor receptor alpha (PDGFR-alpha), a putative rece...

Journal: :Science 2003
Philippe Boucher Michael Gotthardt Wei-Ping Li Richard G W Anderson Joachim Herz

Vascular smooth muscle cell (SMC) proliferation and migration are important events in the development of atherosclerosis. The low-density lipoprotein receptor-related protein (LRP1) mediates suppression of SMC migration induced by platelet-derived growth factor (PDGF). Here we show that LRP1 forms a complex with the PDGF receptor (PDGFR). Inactivation of LRP1 in vascular SMCs of mice causes PDG...

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