Peptide deformylase (PDF) is a metalloprotease catalyzing the removal of a formyl group from newly synthesized proteins, which makes it an important antibacterial drug target. Given the importance of PDF inhibitors like actinonin in antibacterial drug discovery, several reported potent PDF inhibitors were used to develop pharmacophore models using the Galahad module of Sybyl 7.1 software. Gener...

Peritoneal dialysate fluid (PDF) is a bacteriostatic medium that compromises the antibacterial activity of cell wall-active agents. By use of an in vitro static model, methicillin-resistant Staphylococcus aureus (MRSA), methicillin-susceptible S. aureus (MSSA), methicillin-susceptible Staphylococcus epidermidis (MSSE), and Streptococcus sanguis were exposed to daptomycin at concentrations of 10...

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In probability density function (PDF) methods of turbulent flows, the joint PDF of several flow variables is computed by numerically integrating a system of stochastic differential equations for Lagrangian particles. A set of parallel algorithms is proposed to provide an efficient solution of the PDF transport equation modeling the joint PDF of turbulent velocity, frequency and concentration of...

The ability of the pair distribution function (PDF) analysis of total scattering (TS) from a powder to determine the local ordering in ferroelectric PZN (PbZn1/3Nb2/3O3) has been explored by comparison with a model established using single-crystal diffuse scattering (SCDS). While X-ray PDF analysis is discussed, the focus is on neutron diffraction results because of the greater extent of the da...

The probability distribution functions (PDF) of density of the interstellar medium (ISM) in galactic disks and global star formation rate are discussed. Three-dimensional hydrodynamic simulations show that the PDFs in globally stable, inhomogeneous ISM in galactic disks are well fitted by a single lognormal function over a wide density range. The dispersion of the log-normal PDF (LN-PDF) is lar...

Title Type development of intersensory perception comparative perspectives PDF development of perception psychobiological perspectives volume 2 the visual system PDF comparative perspectives on the development of memory PDF comparative perception discrimination PDF comparative perception communication PDF development of perception cognition and language PDF comparative criticism east and west c...

A particle method applying the probability density function ~PDF! approach to turbulent compressible flows is presented. The method is applied to several turbulent flows, including the compressible mixing layer, and good agreement is obtained with experimental data. The PDF equation is solved using a Lagrangian/Monte Carlo method. To accurately account for the effects of compressibility on the ...

Title Type advances in rule interchange and applications international symposium ruleml 2007 orlando florida PDF rule based reasoning programming and applications 5th international symposium ruleml 2011 europ PDF advances in computation and intelligence second international symposium isica 2007 wuhan china s PDF stochastic algorithms foundations and applications 4th international symposium saga...