catheter ablation is an accepted, highly effective modality of treatment for cardiac arrhythmias in children. the success rate depends on the operator’s experience, especially in cases involving complex anatomies. we hereby report our recent experience of successful ablation of accessory pathways in three children with complex congenital heart diseases. the first case was a 7-year-old girl with...

It is estimated that up to 20% of all types of human cancers worldwide are attributed to viruses. The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation. The modulation of cell cycle control mechanisms, cellular regulatory and signaling pathways by oncogenic viruses, plays an important role in viral carcinogenes...

One of the important parts of innate immunity is complement system that occurs in three different ways; the classic, the alternative and the lectin pathway. The four pattern recognition molecules that have been identified till now are Mannose binding lectin (MBL), a component of lectin pathway, and three ficolins (ficolin1,-2 and -3) which compound to the carbohydrates of the cell surface. MBL ...

Background and objectives: Positive role of saffron in human health promotion has been investigated in widespread researches. Anticancer property, neuroprotection, protection of cardiovascular system and several positive properties are reported for saffron customers. The aim of this study was assessment of saffron weakness against light damage in rat retina. Methods:</s...

The topology-based pathway analysis methods test one of the two types of null hypotheses as proposed in [6] for gene set enrichment analysis. The first hypothesis expects the genes in a pathway to be at most as often differentially expressed as the genes outside the pathway (the remaining genes measured in the experiment). Methods testing this hypothesis typically use gene randomization in the ...

Minepath ( www.minepath.org ) is a web-based platform that elaborates on, and radically extends the identification of differentially expressed sub-paths in molecular pathways. Besides the network topology, the underlying MinePath algorithmic processes exploit exact gene-gene molecular relationships (e.g. activation, inhibition) and are able to identify differentially expressed pathway parts. Ea...

Recent advancement in microarray technologies and large high throughput data generated has made it very challenging to decipher and draw a feasible biological conclusion from current microarray experiments. The difficulty arises when the number of samples available for analysis is smaller than the huge numbers of genes that need to be considered. Currently, pathway analysis is a preferable tool...

Catharanthus roseus L. is an important medicinal plant producing several terpenoid indole alkaloids (TIAs) such as vincristine and vinblastine secondary metabolites with anticancer activity. The TIAs biosynthetic pathways are affected by biotic and abiotic stresses. In this study the effect of drought (7 days), salinity (150 mM NaCl), foliar spray of salicylic acid (10-5 M) and salicylic acid i...