K(2P) channels mediate potassium background currents essential to central nervous system function, controlling excitability by stabilizing membrane potential below firing threshold and expediting repolarization. Here, we show that alternative translation initiation (ATI) regulates function of K(2P)2.1 (TREK-1) via an unexpected strategy. Full-length K(2P)2.1 and an isoform lacking the first 56 ...

In an exercise in the first volume of his famous series of books, Knuth considered sorting permutations by passing them through a stack. Many variations of this exercise have since been considered, including allowing multiple passes through the stack and using different data structures. We are concerned with a variation using pop-stacks that was introduced byAvis andNewborn in 1981. Let Pk(x) b...

Multi-core processors have recently been available on most personal computers. To get the maximum benefit of computational power from the multi-core architecture, we need a new design on existing algorithms and software. In this paper we propose the parallelization of the well-known k-means clustering algorithm. We employ a single program multiple data (SPMD) approach based on a message passing...

T HE CELL MEMBRANE of mammalian heart muscle cells may be characterized by three interrelated observations. In the first place, the membrane separates an intracellular solution having a high potassium (K) and a low sodium (Na) concentration from an ex-tracellular solution with a high Na and low K concentration. Secondly, K and Na ions can be shown with radioactive tracer technics to be continuo...

This paper considers the k-set-agreement problem in a synchronous message passing distributed system where up to t processes can fail by crashing. We determine the number of communication rounds needed for all correct processes to reach a decision in a given run, as a function of k, the degree of coordination, and f ≤ t the number of processes that actually fail in the run. We prove a lower bou...

Let Jα k be a real power of the integration operator Jk defined on Sobolev space W k p [0, 1]. We investigate the spectral properties of the operator Ak = ⊕n j=1 λjJ α k defined on ⊕n j=1W k p [0, 1]. Namely, we describe the commutant {Ak} ′, the double commutant {Ak} ′′ and the algebra AlgAk. Moreover, we describe the lattices LatAk and HypLatAk of invariant and hyperinvariant subspaces of Ak,...

.Let P be a polygonal line approximating a planar curve curve Γ, the discrete curvature kd(P) at a vertex P ∈ P is (usually) defined to be the quotient of the angle between the normals of the two segments with vertex P by the average length of these segments. In this article we give an explicit upper bound of the difference |k(P)− kd(P)| between the curvature k(P) at P of the curve and the disc...

The rates of tautomerization of 2-nitrocyclohexanone (2-NCH) have been measured spectrophotometrically at 25.0 +/- 0.1 degrees C in several organic aprotic solvents and their binary mixtures. In cyclohexane the reaction is effectively catalyzed by bases and inhibited by acids while the so-called "spontaneous reaction" appears essentially due to autocatalysis. Apparent second order rate constant...