Data clustering is one of the important data mining methods. It is a process of finding classes of a data set with most similarity in the same class and most dissimilarity between different classes. The well known hard clustering algorithm (K -means) and Fuzzy clustering algorithm (FCM) are mostly based on Euclidean distance measure. In this paper, a comparative study of these algorithms with d...

Zinc oxide nanoparticles (ZnO NPs) have been widely used in consumer products, therapeutic agents, and drug delivery systems. However, the fate and behavior of ZnO NPs in living organisms are not well described. The purpose of this study was to develop a physiologically based pharmacokinetic model to describe the dynamic interactions of (65)ZnO NPs in mice. We estimated key physicochemical para...

The present QSAR study has attempted to explore the structural and physicochemical requirements of ligands N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for binding with peripheral benzodiazepine receptor (PBR). The calculated partition coefficient values show parabolic relations with the PBR binding affinity, suggesting that the binding affinity increases with increase in the partition coeffici...

We examine a linear programming problem formulation in which the constraint coefficients are not precisely given in the work. We investigate the possibility of applying GAs to solve this kind of fuzzy linear programming problem without defining membership functions for fuzzy numbers, using the extension principle, interval arithmetic, and α-cut operations for fuzzy computations, and using a pen...

ABsTRAcr The conditions under which the partial pressure of a solvent in the alveolar gas is likely to provide a valid index of its partial pressure in the mixed venous blood, and thus of whole-body exposure, is explored on a theoretical basis. Under steady-state conditions, providing the solvent's blood/gas partition coefficient exceeds 10, its mixed venous and alveolar pressures will agree wi...

In this paper we improve a method of Robinson and Taulbee for computing Kronecker coefficients and show that for any partition ν of d there is a polynomial kν with rational coefficients in variables xC , where C runs over the set of isomorphism classes of connected skew diagrams of size at most d, such that for all partitions λ of n, the Kronecker coefficient g(λ, λ, (n − d, ν)) is obtained fro...

The aqueous solubility (logW) and n-octanol/water partition coefficient (logP(OW)) are important properties for pharmacology, toxicology and medicinal chemistry. Based on an understanding of the dissolution process, the frontier orbital interaction model was suggested in the present paper to describe the solvent-solute interactions of organohalogen compounds and a general three-parameter model ...