single-particle process Consider a single particle of volume V ( t ) at time t which undergoes random, discontinuous “erosion” to smaller sizes in accord with the probabilistic law: Pr( V ( t + d t ) I u I V ( f ) = u’ 1 = B ( u I u’ )dt We let F( u, t ) be the cumulative distribution function for the size of the single particle undergoing random erosion. Suppose that the cumulative probability...

The Nijmegen breakage syndrome is a rare autosomal recessive chromosomal instability disorder characterized by early growth retardation, congenital microcephaly, immunodeficiency, borderline mental development, and a high tendency to lymphoreticular malignancies. Most Nijmegen breakage syndrome patients are of Slavonic origin, and all of them known so far carry a founder homozygous 5 nucleotide...

The evolution of frictional strength during stick-slip dynamics a fault system is key to understanding earthquake nucleation and rupture patterns. In mature faults, granular gouge produced by wear, comminution or fragmentation tectonic movements. this work, we introduce model in the simulation sheared explore influence grain breakage on dynamics. With highly stressed particles, increases accomp...

Coal mine waste rocks, mainly broken gangue, can be used as filling materials to backfill into goafs. Under the overburden load, body is vulnerable compressive deformation and particle breakage. With increase in mining depth, overlying strata will impose different loads on rock at loading velocities, which further affect material In this paper, an experimental scheme a device are designed study...

Chromosome breakage as a result of replication stress has been hypothesized to be the direct consequence of defective replication fork progression, or "collapsed" replication forks. However, direct and genome-wide evidence that collapsed replication forks give rise to chromosome breakage is still lacking. Previously we showed that a yeast replication checkpoint mutant mec1-1, after transient ex...

Abstract Purpose Multimodal effective particle size distributions (EPSDs) develop as flocculation and breakage occur dynamically in a fluid shear such have been previously reported coastal estuarine waters to understand processes. Here, we use time varying multimodal EPSDs hydraulic parameters (discharge bed stress) assess freshwater gravel-bed river southern Alberta, Canada. Methods Instantane...

The transposable Dissociation (Ds) element of maize was first discovered as a site of high-frequency chromosome breakage. Because both Ds-mediated breakage and transposition require the presence of the Activator (Ac) element, it has been suggested that chromosome breakage may be the outcome of an aberrant transposition event. This idea is consistent with the finding that only complex structures...

Objectives: To identify (1) the prevalence of condom breakage, and demographic and sexuality-related differences among young men who have sex with women reporting and not reporting this event; (2) condomspecific behaviours associated with breakage. Methods: Young men (n = 278) attending a clinic for treatment of sexually transmitted infections (STIs) responded to an anonymous questionnaire aide...