BACKGROUND The effects of PIM-1 on the progression of pancreatic cancer remain unclear, and the prognostic value of PIM-1 levels in tissues is controversial. Additionally, the expression levels and clinical value of PIM-1 in plasma have not been reported. METHODS The effects of PIM-1 on biological behaviours were analysed. PIM-1 levels in tissues and plasma were detected, and the clinical val...

In an increasingly complex world where people routinely handle large amounts of information, individuals are constantly challenged to manage and effectively use the information that they are responsible for. While email is the canonical example of an information overloading application, other well-known personal information management (PIM) applications and tasks cited in earlier chapters of th...

BACKGROUND Pim-1 (Provirus integration site for Moloney murine leukemia virus 1) belongs to the Ser/Thr kinase family and plays a pivotal role in occurrence and development of oncogenesis. Recent studies have demonstrated that Pim-1 phosphorylates RUNX3 and alters its subcellular localization. However, few studies have concerned the implications of Pim-1 in the salivary gland adenoid cystic car...

BACKGROUND Nasal saline irrigation is a common component of chronic rhinosinusitis (CRS) management. The benefits of irrigation have been noted in primary and postoperative management of CRS. The irrigation consists of physiologic saline solution applied into a nostril via a squeeze-bottle, a bulb syringe, or a neti pot. As the saline flows through the nasal cavity from anterior to posterior, t...

A laboratory soil column experiment was first conducted to analyze water movement in latosol of sugarcane field under drip irrigation from single-point source at different emitter discharge rates. Next, a mathematical model of soil water movement under drip irrigation from single-point source was built using Hydrus-3D, which could accurately simulate the shape of the wetted soil volume and the ...

The PIM family of oncogenic serine/threonine kinases regulates tumour cell proliferation. To identify proliferative signaling pathways that are regulated by PIM kinases we analyzed gene expression differences in DU-145 and PC3 prostate cancer derived cells induced by treatment with the recently developed highly selective PIM kinase inhibitor M-110. This identified 97 genes the expression of whi...

PURPOSE Potentially Inappropriate Medications (PIM) use in elderly people may be responsible for the development of Adverse Drug Reaction (ADR) which, when severe, leads to hospital admissions. OBJECTIVES to estimate the prevalence of elderly who had used PIM before being admitted to hospital admission and to identify the risk factors and the hospitalizations related to ADR arising from PIM. ...

Provirus integration site for Moloney murine leukemia virus (Pim-1) is an oncoprotein overexpressed in lungs from pulmonary arterial hypertension (PAH) patients and involved in cell proliferation via the activation of the NFAT/STAT3 signaling pathway. We hypothesized that Pim-1 plasma levels would predict the presence of PAH and correlate with disease severity. Pim-1 plasma levels were measured...

The relative reduction in potential ground-water contamination due to pesticides at several sites in Utah was determined by comparing alternative irrigation system designs, water management practices and pesticides. Alternative sprinkler irrigation distribution coefficients were used to estimate infiltration depths. The movement of pesticides through soils following sprinkler irrigations was si...