This study presents a preliminary trial for a new classification of cholesteatoma that allow comparison of cases and standardization of management. All previous attempts failed to gain acceptance because of the lack of clinical relevance. Objective: Trial of a new simple practical system to stage cholesteatoma based only on the extent of the lesion, utilizing microscopic and endoscopic examinat...

OBJECTIVES To investigate the expression of prostaglandin E2 receptor subtypes, E-prostanoid (EP) 1-4 receptors, in acquired cholesteatoma and its possible role in the pathologic process of this disorder. METHODS Specimens of human acquired cholesteatoma were obtained from 29 patients and 19 skin biopsies of normal external auditory canal were as controls. The mRNA and protein expression of E...

UNLABELLED Conventional CT and MRI scans have low specificity when it comes to differentiating granulation tissue from relapsing cholesteatoma. AIM this paper aims to analyze the use of DWI and delayed post-contrast T1-weighed imaging in the detection of recurring cholesteatomas. MATERIALS AND METHOD this is a cross-sectional prospective study that looked at 17 cholesteatoma patients postop...

OBJECTIVE To describe the clinical manifestations of external auditory canal (EAC) cholesteatoma and evaluate the surgical outcomes of reconstruction using an inferior pedicled soft-tissue periosteum flap. MATERIALS AND METHODS A total of 28 patients were enrolled in this retrospective study conducted at Kaohsiung Medical University Hospital in Taiwan between January 2004 and December 2013. E...

A escritora Maura Lopes Cançado (1929-1993), nascida em São Gonçalo do Abaeté-MG, inaugura a escrita autobiográfica de autoria feminina louca na literatura brasileira. Em sua obra Hospício é deus – diário I, publicada 1965, destaca-se rubrica da loucura, constituindo-se assim letra descentrada arena literária contexto publicação. Circunscrita tanto no campo conhecimento histórico como área cria...

Cholesteatomas are benign epidermally‑derived lesions of the temporal bone that are caused by migration of hyperproliferative keratinocytes into the middle ear and mastoid cavity. The molecular mechanisms that regulate the pathogenesis of cholesteatomas are currently not fully understood. The present study demonstrated the antigrowth and anti‑invasive effects of let‑7a microRNA (miRNA) on chole...

Combined use of an operating microscope and a middle ear endoscope seems to be helpful for selecting an appropriate surgical technique and for identifying more patients in whom cholesteatoma can be removed by a trans-canal approach alone. To investigate whether attic cholesteatoma can be treated by a trans-canal approach alone, a review was performed of patients who had undergone endoscopically...

INTRODUCTION AND PURPOSE Diffusion weighted imaging (DWI) has been proven to be valuable in the diagnosis of middle ear cholesteatoma. The aims of our study were to evaluate the advantage of multi-shot turbo spin echo (MSh TSE) DWI compared to single-shot echo-planar (SSh EPI) DWI for the diagnosis of cholesteatoma. MATERIAL AND METHODS Thirty-two patients with clinical suspicion of unilatera...

OBJECTIVES/HYPOTHESIS To evaluate the correlation between the surgeon's intraoperative findings and histopathologic diagnosis of cholesteatoma specimens and the associated health care cost in requesting pathologic evaluation. STUDY DESIGN Retrospective chart analysis. METHODS Chart data were collected at a tertiary neurotology referral center from patients undergoing tympanomastoidectomy fo...