Focal epithelial hyperplasia (FEH) or Heck’s disease is a rare viral infection of the oral mucosa caused by human papilloma virus especially subtypes 13 or 32. The frequency of this disease varies widely from one geographic region and ethnic groups to another. This paper reports an Iranian case of extensive focal epithelial hyperplasia. A 35-year-old man with FEH is described, in whom the lesio...

Three out of four carcinomas arising from rims-induced, rabbit papillomas have grown well after transplantation to sucklings. Two were propagated serially, and it seems likely that all could have been maintained indefinitely had litters been available of newborn animals of the sort in which they arose. These successes are the more worthy of note because of the well-nigh uniform failure of simil...

Objective Sinonasal inverted papilloma (IP) is a benign and uncommon tumor of the nasal cavity and paranasal sinuses with a tendency for recurrence and even malignant transformation. Though the morphology and clinical behavior of this lesion has been well described, its etiology remains controversial. Methods Computerized searches were performed in PubMed, Scopus, and Google scholar through M...

The Vx2 and Vx7 rabbit carcinomas, both of Shope papilloma derivation, were cultivated in vitro and studied for immunofluorescence indicative of the presence of viral antigen. The cultured Vx7 cells were characteristically pleomorphic, round or polygonal cells, and immunofluorescence was demonstrable in 5-20% of them as counted on cover slip cultures after exposure to rabbit sera containing ant...

Virus-induced papillomas (Shope) on domestic rabbits are susceptible to Roentgen rays. The dosage which uniformly brings about their complete and permanent disappearance has been found to be 3600 r (200 kilovolts), whether this dose be administered at one time or fractionally. 60 per cent of the tumors are cured when irradiated with 3000 r.