FAMILIAL NONMEDULLARY THYROID CANCER (Abstract): Follicular cell-derived thyroid cancer which represents 90-95% of all thyroid malignancies may occur in at least 5% of cases as familial disease. Familial nonmedullary thyroid cancer (FNMTC) is defined as the existence of two or more first degree relatives affected within a family. FNMTC may occur in two situations: pure FNMTC in which FNMTC is t...

Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid. Majority of the PTC carries an excellent prognosis. However, patients with tall cell variant (TCV) of papillary thyroid carcinoma have a worse prognosis than those with the classic variant. On the other hand, squamous cell carcinoma of the thyroid (SCT) is an unusual neoplasm thought to arise as a primary tu...

Thyroid cancer is a rare disease. Aetiological factors are increased secretion of TSH and exposure of the growing gland to ionizing radiation. Pathological classification is in two main groups: differentiated and undifferentiated. Differentiated is subdivided into papillary, follicular and medullary. Papillary and medullary carcinomas occur in young patients, grow slowly, spread by lymphatics. ...

Since the FDA approved sorafenib use for thyroid cancer, administration of this medicine to thyroid-cancer patients had steadily increased. However, an appropriate starting dose for this treatment has not been established, which is problematic because the sorafenib discontinuation rate due to toxicity is higher among thyroid cancer patients than among patients with other solid tumors. We recent...

Long-term treatment with minocycline is occasionally associated with the development of black thyroid syndrome in which thyroid cancer is frequently found. Here, we report a patient with cutaneous, pulmonary and thyroid sarcoidosis who developed papillary thyroid carcinoma in the presence of a black thyroid syndrome after being treated with minocycline for 2.5 years.

Hypermethylation leading to the loss of hypermethylated in cancer-1 (HIC1) gene expression occurs in many different types of human cancer. HIC1 is a transcriptional repressor that directly binds to the promoter region of NAD-dependent deacetylase sirtuin-1 (SIRT1). SIRT1 functions in cell growth, is anti-apoptotic, protect neurons, functions in senescence, and regulates energy restriction. Epig...

BACKGROUND Parathyroid metastatic disease from thyroid cancer has not been studied extensively, mainly due to the need for parathyroid preservation during thyroid surgery. METHODS We reviewed files from 1,770 patients with thyroid cancer followed up in our department and 10 patients with parathyroid metastases (0.5%) were identified. Patient and tumor characteristics were recorded. RESULTS ...

TSH stimulation of sodium iodide symporter (NIS) expression in thyroid cancer promotes radioiodine uptake and is required to deliver an effective treatment dose. Activation of the insulin/phosphoinositide-3-kinase (PI3K) signaling pathway in TSH-stimulated thyroid cells reduces NIS expression at the transcriptional level. We, therefore, investigated the effects of PI3K pathway inhibition on iod...

Papillary thyroid microcarcinoma (PMC) is defined as a papillary carcinoma 1 cm or less in size. PMC is a variant of papillary carcinoma, the most common thyroid cancer, which has a very good prognosis and in which distant metastases and death (0.4--1% per year) are exceptional.1 We report a patient who was diagnosed with metastasis of a papillary microcarcinoma as the result of an evaluation o...

Introduction: While it can be difficult to categorize thyroid lesions, employing ultrasound may enable correct diagnosis, classification, and therapy of nodules, particularly papillary carcinoma the thyroid, assist save unneeded biopsy. Objective: Taking histopathology as gold standard, assessing diagnostic precision in identification cancer nodule patients. Study design: Cross sectional study ...