Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should be considered along with other types of information and health care considerations. The information inclu...

Purpose: Limited drug distribution within solid tumors is an important cause of drug resistance. Basic drugs (e.g., doxorubicin)maybe sequestered in acidic organelles, thereby limiting drug distribution todistal cells and diverting drugs from their target DNA. Here we investigate the effects of pantoprazole, a proton pump inhibitor, on doxorubicin uptake, and doxorubicin distribution and activi...

Background: Clarithromycin resistance is an increasing problem in this part of the world and it potentially has an impact on the eradication rate of first line triple therapy (proton pump inhibitorAmoxicillinClarithromycin) for Helicobacter pylori (H. pylori) infection. Objective: This study was designed to determine the effect of clarithromycin resistance on the efficacy of Pantoprazole-Amoxic...

The synthesis and characterization of solid complexes for pantoprazole sodium sesquihydrate (PNZ) with Cd(II), Hg(II) and Zn(II) metals in molar ratios M:L = 1:2 was studied. The complexes are stable in the solid state and are soluble only in DMF and DMSO. The metal complexes were characterized by elemental analysis, molar conductivity measurements, magnetic susceptibility, UV spectrophotometry...

BACKGROUND Nowadays PPI present cornerstone in the medical therapy of bleeding peptic ulcer. Controlled pantoprazole data in peptic ulcer bleeding are few. AIM To compare the effect of intravenous (iv) pantoprazole (PPI) with iv ranitidine (H2RA) for bleeding peptic ulcers after endoscopic therapy. METHODS After endoscopic haemostasis, 122 patients were randomized to PPI 80 mg + 8 mg/h or H...

BACKGROUND Our aim was to prospectively assess the potential influence of pantoprazole therapy on the antiplatelet effects of acetylsalicylic acid (ASA) and clopidogrel (CLO) in stable angina pectoris (SAP) patients after percutaneous coronary intervention (PCI). METHODS Forty-four patients with SAP (CCS I-III) and successful PCI with stent implantation were enrolled into the study. The patie...

Background: The aim was determining bioequivalence between pantoprazole buffered powder for oral suspension and enteric coated tablets under fasting conditions in healthy volunteers.Methods: In randomized cross-over study, participants were administered a single dose of as 40 mg (sodium bicarbonate buffer) or one tablet mg, with 240±2 ml water per the randomization schedule each study period. B...