There is no doubt that pancreatic cancer one of the most deadly types cancer. In order to diagnose and stage tumors, computed tomography (CT) widely used. However, manual segmentation volumetric CT scans a time-consuming subjective process. It has been shown U-Net model highly effective for semantic segmentation, although several deep learning models have proposed. this study, we propose U-Net-...

Liver transplantation has been recognized as the treatment for various kinds of end-stage liver diseases. Standardized surgical technique, potent immunosuppressive agents and diligent postoperative care have made it possible for patients to survive for a longer period. For this reason, recurrent primary disease and/or de novo malignancy regarded as chronic immunosuppressant have been paid a gre...

A large body of evidence suggests that cyclooxygenase-2 (COX-2) is important in gastrointestinal cancer. The purpose of this study was to determine whether COX-2 was expressed in adenocarcinoma of the human pancreas. Quantitative reverse transcription-PCR, immunoblotting, and immunohistochemistry were used to assess the expression of COX-2 in pancreatic tissue. Levels of COX-2 mRNA were increas...

PURPOSE METH-1/hADAMTS-1 and METH-2/hADAMTS-8 are recently identified genes that inhibit angiogenesis, and the murine homologue, ADAMTS-1, shows metalloproteinase function. Because the significance of METH-1 and METH-2 has not been determined in solid tumors, we examined the mRNA expressions of these molecules in pancreatic cancer and hepatocellular carcinoma (HCC). EXPERIMENTAL DESIGN METH-1...

The majority of human pancreatic adenocarcinomas display a ductal phenotype; experimental studies indicate that tumors with this phenotype can arise from both acinar and ductal cells. In normal pancreas acinar cells, the pancreas transcription factor 1 transcriptional complex is required for gene expression. Pancreas transcription factor 1 is a heterooligomer of pancreas-specific (p48) and ubiq...