Androgen insensitivity syndrome (AIS) is a rare X-linked recessive disorder occurring in phenotypic women with male genotype (46, XY) resulting due to mutation the X chromosome. On other hand, tuberculosis (TB) chronic granulomatous infection caused by Mycobacterium tuberculosis, an acid-fast bacillus. We report case of 22-year-old unmarried female presenting bilateral inguinal pain and primary...

Identification of genes associated with pain insensitivity syndromes can increase the understanding of the pathways involved in pain and contribute to the understanding of how sensory pathways relate to other neurological functions. In this report we describe the mapping and identification of the gene responsible for loss of deep pain perception in a large family from northern Sweden. The loss ...

Patients with schizophrenia have been shown to display decreased sensitivity to pain, which can severely compound the impact of injuries and illnesses. Alterations in the sensory and affective systems of pain processing have been proposed as mechanisms, but the unique contribution of each of these systems has not been elucidated. The aim of this study was to investigate these two components of ...

It is well documented that borderline personality disorder (BPD) is characterized by reduced pain sensitivity, which might be related to nonsuicidal self-injury and dissociative experiences in patients with BPD. However, it remains an open question whether this insensitivity relies at least partly on altered sensory integration or on an altered evaluation of pain or a combination of both. In th...

OBJECTIVES The NTRK1 gene plays an important role in sensory and sympathetic neuronal survival. Mutations in this gene cause a rare hereditary disease known as congenital insensitivity to pain with anhidrosis. The aim of this study was to explore possible associations between single-nucleotide polymorphisms (SNPs) in NTRK1 and pain perception in a selected population. METHODS A total of 309 h...

The problem of pain, since the beginning of this century, has been dominated by the concept that pain is purely a sensory experience. Yet it has a unique, distinctively unpleasant, affective quality that differentiates it from sensory experiences such as sight, hearing or touch. . . . The motivational-affective dimension of pain is brought clearly into focus by clinical studies on frontal lobot...