نتایج جستجو برای: p53 gene

تعداد نتایج: 1168151  

Journal: :Human mutation 2003
Shoshana Peller Varda Rotter

Inactivation of the wild-type p53 gene (TP53) by various genetic alterations is a major event in human tumorigenesis. More than 60% of human primary tumors exhibit a mutation in the p53 gene. Hematological malignancies present a rather low incidence of genetic alterations in this gene (10-20%). Nevertheless, epidemiological studies of the hematological malignancies indicate that the prognosis o...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1998
D K Frank T J Liu M J Frederick G L Clayman

Ample data exist contending that wild-type p53 and E2F-1 cooperate to mediate apoptosis, that E2F-1-mediated apoptosis is p53 dependent in some situations, and that E2F-1 can induce accumulation of p53 in mammalian cells. These data support the investigation of the biological consequences of combined wild-typep53 and E2F-1 overexpression in human squamous cell carcinoma of the head and neck (SC...

Journal: :The Kaohsiung journal of medical sciences 2005
Hung-Yu Lin Chun-Hsiung Huang Wen-Jen Wu Yii-Her Chou Pao-Luo Fan For-Wey Lung

Early detection of a mutated p53 gene is thought to provide useful information in a wide range of human tumors. The aim of this study was to identify the role of the p53 gene in transitional cell carcinoma of the urinary tract. From March 1992 to July 2003, 75 patients (54 men and 21 women) with a mean age of 66.85 years and pathologically diagnosed transitional cell carcinoma were enrolled in ...

Journal: :American journal of physiology. Renal physiology 2005
Hao Fan Jessica R Harrell Susana Dipp Zubaida Saifudeen Samir S El-Dahr

Gene-environment interactions are implicated in congenital human disorders. Accordingly, there is a pressing need to develop animal models of human disease, which are the product of defined gene-environment interactions. Previously, our laboratory demonstrated that gestational salt stress of bradykinin B(2) receptor (B(2)R)-null mice induces renal dysgenesis and early death of the offspring. In...

Journal: :Cancer research 1996
S C Righetti G Della Torre S Pilotti S Ménard F Ottone M I Colnaghi M A Pierotti C Lavarino M Cornarotti S Oriana S Böhm G L Bresciani G Spatti F Zunino

The p53 protein is a multifunctional transcriptional regulator involved in cellular response to DNA damage and has been implicated as a putative determinant of sensitivity of tumor cells to cytotoxic agents. Since the p53 gene becomes inactivated in over one-half of advanced ovarian carcinoma, in this study we have examined the relationships between p53 gene alterations, p53 immunoreactivity, a...

Journal: :Cold Spring Harbor perspectives in biology 2009
Wenwei Hu

The p53 family of genes (p53, p63, and p73) is conserved over evolutionary time scales. Although the functions of p53 gene and its protein as a tumor suppressor have been firmly established, the earliest functions for the p53 ancestral genes in worms and flies are to ensure germ-line genomic integrity and the fidelity of the developmental process. In vertebrates, the p53 family of genes retains...

2015
Xingxing He Jiazhi Liao Fang Liu Junwei Yan Jingjun Yan Haitao Shang Qian Dou Ying Chang Jusheng Lin Yuhu Song

Mutation in the p53 gene is arguably the most frequent type of gene-specific alterations in human cancers. Current p53-based gene therapy contains the administration of wt-p53 or the suppression of mutant p53 expression in p53-defective cancer cells. . We hypothesized that trans-splicing could be exploited as a tool for the correction of mutant p53 transcripts in p53-mutated human colorectal ca...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Kotaro Kameyama Cheng-long Huang Dage Liu Daiki Masuya Takashi Nakashima Shinichi Sumitomo Yuji Takami Moritoshi Kinoshita Hiroyasu Yokomise

PURPOSE We performed a clinical study on ING1b gene expression and p53 gene status in relation to p53 target genes. EXPERIMENTAL DESIGN Eighty-eight tumors from surgically treated non-small cell lung cancer (NSCLC) patients were studied. PCR-single-strand conformational polymorphism after sequencing was performed to investigate ING1 and p53 gene status. Quantitative reverse transcription-PCR ...

Journal: :Blood 1991
K Sugimoto H Toyoshima R Sakai K Miyagawa K Hagiwara H Hirai F Ishikawa F Takaku

p53 is currently considered to be a tumor suppressor gene product, and its alterations are suggested to be involved in several human malignancies. Here we show evidence of the possible involvement of p53 gene mutations in lymphoid leukemias studied by reverse transcriptase-polymerase chain reaction, single strand conformation polymorphism analysis, and nucleotide sequencing. Fourteen patients w...

Journal: :Arthritis Research & Therapy 2006
Xin You David L Boyle Deepa Hammaker Gary S Firestein

PUMA (p53-upregulated modulator of apoptosis) is a pro-apoptotic gene that can induce rapid cell death through a p53-dependent mechanism. However, the efficacy of PUMA gene therapy to induce synovial apoptosis in rheumatoid arthritis might have limited efficacy if p53 expression or function is deficient. To evaluate this issue, studies were performed to determine whether p53 is required for PUM...

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