PURPOSE Resistance is commonly acquired in patients with metastatic gastrointestinal stromal tumor who are treated with imatinib mesylate, often due to the development of secondary mutations in the KIT kinase domain. We sought to investigate the efficacy of second-line tyrosine kinase inhibitors, such as sorafenib, dasatinib, and nilotinib, against the commonly observed imatinib-resistant KIT m...

This project investigates the development of automated tools for video monitoring using multiple cameras in support of security applications. The project has both experimental and theoretical components. In Year 5, we focused on two problems of critical operational interest to surveillance and security in mass transit environments: the automatic, real-time detection of counterflow (e.g., passen...

In this paper, we investigate the structure of cyclic codes over the ring F3 + vF3 where v2 = 1 and F3 = {0, 1, 2}. We prove that cyclic codes over the ring are principally generated, and give the generator polynomial of cyclic codes over this ring. Mathematics Subject Classification: 94B05

Let t ≥ 26 and let F be a k-uniform hypergraph on n vertices. Suppose that |F1∩F2∩F3| ≥ t holds for all F1,F2,F3 ∈F . We prove that the size of F is at most (n−t k−t ) if p = k n satisfies p≤ 2 √ 4t +9−1 and n is sufficiently large. The above inequality for p is best possible.

BACKGROUND The aim of this study was to develop a method to separate and quantify subforms of free prostate-specific antigen (fPSA) in serum by two-dimensional electrophoresis and to assess the diagnostic accuracy of these subforms for prostate cancer (PCa) diagnosis in comparison with total PSA (tPSA) and the ratio of fPSA to tPSA (%fPSA). METHODS Sera from 50 patients with and without PCa, ...

The adaptor protein Grb10 plays important roles in mitogenic signaling. However, its roles in acute myeloid leukemia (AML) are predominantly unknown. Here we describe the role of Grb10 in FLT3-ITD-mediated AML. We observed that Grb10 physically associates with FLT3 in response to FLT3-ligand (FL) stimulation through FLT3 phospho-tyrosine 572 and 793 residues and constitutively associates with o...

Although mortality related with primary tumors is approximately 10%, metastasis leads to 90% of cancer-associated death. The majority of brain metastases result from lung cancer, but the metastatic mechanism remains unclear. In general, chemotherapy for treating brain diseases is disrupted by the brain blood barrier (BBB). As an approach to improv...

PURPOSE Medulloblastoma, a malignant pediatric brain tumor, is incurable in about one third of patients despite multimodal treatments. In addition, current therapies can lead to long-term disabilities. Based on studies of the extensive tropism of neural stem cells (NSC) toward malignant gliomas and the secretion of growth factors common to glioma and medulloblastoma, we hypothesized that NSCs c...

To identify domains in hematopoietic growth factor receptors that are important for signal transduction, a hybrid receptor (GMER) was constructed by splicing the DNA of the entire extracellular and transmembrane domains of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha 2 subunit (GMR) to the cytoplasmic domain of the murine erythropoietin receptor (mEpoR). Th...