نتایج جستجو برای: p value
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Pathway analysis approaches for sequence data typically either operate in a single stage (all variants within all genes in the pathway are combined into a single, very large set of variants that can then be analyzed using standard "gene-based" test statistics) or in 2-stages (gene-based p values are computed for all genes in the pathway, and then the gene-based p values are combined into a sing...
OBJECTIVES Procedures for controlling the false positive rate when performing many hypothesis tests are commonplace in health and medical studies. Such procedures, most notably the Bonferroni adjustment, suffer from the problem that error rate control cannot be localized to individual tests, and that these procedures do not distinguish between exploratory and/or data-driven testing vs. hypothes...
BACKGROUND This study was conducted to find out the age when tibiofemoral angle starts to be in valgus and reaches maximum angle. The differences of the angles between genders were also studied. METHODOLOGY This cross sectional study on tibiofemoral angle was conducted among 160 normal healthy children using clinical measurement method. The children between 2 18 months to 6 years old were ass...
Erratum Following publication of the original article [1], the authors became aware that a sentence in the abstract was not corrected from a previous version of the manuscript. Instead of: “HIV infection (OR 2.73; 95 % CI: 1.704.38), being female (OR: 1.39; 95 % CI 1.31-1.91) and lack of laboratory confirmation (OR: 1.51; 95 % CI 1.102.08) were associated with dying during the course of TB trea...
BACKGROUND Readers may question the interpretation of findings in clinical trials when multiple outcome measures are used without adjustment of the p-value. This question arises because of the increased risk of Type I errors (findings of false "significance") when multiple simultaneous hypotheses are tested at set p-values. The primary aim of this study was to estimate the need to make appropri...
When evaluating the validity of a study, the reader must consider both the clinical and statistical significance of the findings. A study that claims clinical relevance may lack sufficient statistical significance to make a meaningful statement. Conversely, a study that shows a statistically significant difference in 2 treatment options may lack practicality. The concept of power of a clinical ...
OBJECTIVE Time-lag from study completion to publication is a potential source of publication bias in randomised controlled trials. This study sought to update the evidence base by identifying the effect of the statistical significance of research findings on time to publication of trial results. DESIGN Literature searches were carried out in four general medical journals from June 2013 to Jun...
In addition to methods that can identify common variants associated with susceptibility to common diseases, there has been increasing interest in approaches that can identify rare genetic variants. We use the simulated data provided to the participants of Genetic Analysis Workshop 17 (GAW17) to identify both rare and common single-nucleotide polymorphisms and pathways associated with disease st...
We report the first observation of Υ(2S) → ηΥ(1S), with branching fraction B = (2.1 −0.6 (stat.)± 0.3 (syst.))×10−4 and statistical significance 5.3σ. Data were acquired with the CLEO III detector at the CESR e+e− symmetric collider. This is the first process observed involving a b-quark spin flip. For related transitions, 90% confidence limits in units of 10−4 are B[Υ(2S) → π0Υ(1S)] < 1.8, B[Υ...
OBJECTIVE To examine if streamlining a medical research funding application process saved time for applicants. DESIGN Cross-sectional surveys before and after the streamlining. SETTING The National Health and Medical Research Council (NHMRC) of Australia. PARTICIPANTS Researchers who submitted one or more NHMRC Project Grant applications in 2012 or 2014. MAIN OUTCOME MEASURES Average re...
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