BACKGROUND The high cost and undesirable consequences of polypharmacy are well-recognized problems among elderly long-term care (LTC) residents. Despite the implementation of the 1987 Omnibus Budget Reconciliation Act, which requires pharmacist review of drug regimens in this setting, medical and drug costs for LTC residents have continued to increase. OBJECTIVE This study evaluates the North...

Non-cystic fibrosis bronchiectasis (NCFBE) is a rare, chronic lung disease characterized by bronchial inflammation and permanent airway dilation. Chronic infections with P. aeruginosa have been linked to higher morbidity and mortality. To understand the impact of P. aeruginosa in NCFBE on health care costs and burden, we assessed healthcare costs and utilization before and after P. aeruginosa d...

The aim of this study was to evaluate the dependence of Escherichia coli resistance to fluoroquinolones on their use in the outpatients and inpatients in the Hradec Kralove region of the Czech Republic. Data on inpatient fluoroquinolones use were obtained from the database of the Charles University Teaching Hospital Pharmacy and expressed as defined daily dose per 100 beds - days (DBD). Data on...

High-energy phosphate utilization (delta approximately P) associated with force development, force maintenance, and relaxation has been determined during single isometric tetani in the rabbit taenia coli. ATP resynthesis from glycolysis and respiration was stopped without deleterious effects on the muscle. At 18 degrees C and a muscle length of 95% l0, the resting rate of energy utilization is ...

To assess possible cellular mechanisms of in vitro resistance in noninsulin-dependent diabetes mellitus (NIDDM), maximum insulin-stimulated glucose transport and utilization and insulin binding were measured in adipocytes isolated from weight-matched normal glycemic subjects and patients with NIDDM. Glucose transport rate was determined by measuring the amount of [U-14C]-D-glucose taken up by i...

BACKGROUND Population is ageing rapidly and prevalence of cardiovascular diseases is increasing in China. This study aims to examine the patterns of outpatient and inpatient health care utilization across different demographic and socioeconomic groups in older people with cardiovascular disease in China. METHODS Data were from World Health Organization (WHO) Study on Global Aging and Adult He...

A UCT type pilot plant fed with synthetic wastewater was operated with influent COD/TP ratios of 18, 12 and 8 to investigate the role of intracellular storage products on EBPR mechanisms. Acetate was the sole carbon source and other nutrients were provided in excess during plant operation at an SRT value of 10 days and at 20C temperature. COD utilization, P-release and uptake, PHA and glycogen ...

EARLIER studies o f M o h a n and R a d h a (1977) have shown that the ra t io between b lood and bra in choline remains cons tant dur ing aging, however, the level o f acetylcholine (ACh) declines gradual ly wi th advance in age (Mohan , 1976). These results led us to investigate whether the reduced A C h levels in the aged bra in result f rom changes in the kinetic propert ies of the hydro ly...