PURPOSE Evaluation of the possibilities of reducing the accumulation of radiolabeled streptavidin in radiosensitive organs by extracorporeal affinity adsorption (ECAT). EXPERIMENTAL DESIGN Rats were injected with biotinylated antibody and subjected to removal of the antibodies from the circulation by ECAT 24 h after injection (avidin column). Animals were then injected with 111In-1,4,7,10-tet...

Lanthanide-based luminescent ligand binding assays are superior to traditional radiolabel assays due to improving sensitivity and affordability in high-throughput screening while eliminating the use of radioactivity. Despite significant progress using lanthanide(III)-coordinated chelators such as diethylenetriaminepentaacetic acid (DTPA) derivatives, dissociation-enhanced lanthanide fluoroimmun...

The direct instillation of radiolabelled conjugates in the urinary bladder is a promising path for the treatment of bladder carcinoma. The targeting of HER2/neu receptors expressed on the surface of many bladder carcinoma cells shows potential to be developed as a therapeutic strategy, and patients identified with a high risk of progression may benefit from adjuvant targeted radionuclide therap...

The excellent performance of deep neural networks mainly relies on the attributes dataset, such as size, diversity, completeness. However, it is usually difficult to obtain a high-qualified training dataset for some scenarios. Inspired by human visual cognition process with few sample learning, and strong robustness, we believe experience knowledge more powerful than large-scale data. To combin...

It is well established that the mammalian circadian system consists of pacemaker cells in the suprachiasmatic nuclei (SCN). The mouse has become increasingly important in understanding the circadian timing system, due to the availability of mutant animals with abnormal circadian rhythms. In the present paper, we describe the organization of the mouse SCN, comparing the wild type and Clock mutan...

Synchronization between the environmental lighting cycle and the biological clock in the suprachiasmatic nucleus (SCN) is correlated with phosphorylation of the Ca2+/cAMP response element binding protein (CREB) at the transcriptional activating site Ser133. Mechanisms mediating the formation of phospho-CREB (P-CREB) and their relation to clock resetting are unknown. To address these issues, we ...

We present two sampling algorithms for prob­ abilistic confidence inference in Bayesian net­ works. These two algorithms (we call them AIS-BN-p and AIS-BN-li algorithms) guar­ antee that estimates of posterior probabilities are with a given probability within a desired precision bound. Our algorithms are based on recent advances in sampling algorithms for (1) estimating the mean of bounded rand...

We are concerned with the behavior of the eigenvalues of renormalized sample covariance matrices of the form Cn = √ n p ( 1 n A p XnBnX ∗ nA 1/2 p − 1 n tr(Bn)Ap ) as p, n→∞ and p/n→ 0, where Xn is a p×n matrix with i.i.d. real or complex valued entries Xij satisfying E(Xij) = 0, E|Xij | = 1 and having finite fourth moment. A p is a squareroot of the nonnegative definite Hermitian matrix Ap, an...

We introduce a new Bayesian network (BN) scoring metric called the Global Uniform (GU) metric. This metric is based on a particular type of default parameter prior. Such priors may be useful when a BN developer is not willing or able to specify domain-specific parameter priors. The GU parameter prior specifies that every prior joint probability distribution P consistent with a BN structure S is...

The daily timing of rapid eye movement (REM) sleep reflects an interaction between the circadian pacemaker located in the suprachiasmatic nucleus of the hypothalamus (SCN) and a homeostatic process that induces compensatory REM sleep in response to REM sleep loss. Whether the circadian variation in REM sleep propensity is caused by active promotion, inhibition, or passive gating of REM sleep ho...