background : 5-fluorouracil could lead to a decline in fertility in caenorhabditis elegans. the aim of this study was to describe the mechanisms underlying such an altered fertility phenotype and to illustrate the specific genes and path-ways that are involved in the related phenotypic changes in c. elegans. methods : we isolated total rna from the samples and used a new method called digital g...

many parameters affect essential oil yield and chemical composition of aromatic plants. for obtaining the highest quantity and quality of essential oil, it is necessary to know the proper methods of drying and distillation. the aim of this research was to investigate the influence of drying and extraction methods on the yield and chemical composition of the essential oil of eucalyptus sargentii...

abstract: colorectal cancer (crc) is the third most common cancer in men and the second most common cancer in women worldwide. both genetic and epigenetic alterations are common in crc and are the driving force of tumorigenesis. chromosomal instability, microsatellite instability and cpg island methylator phenotype pathways are responsible for genetic instability in colorectal cancer. chromosom...

substance abuse is an important health, psychological and social problem in the world. gabapentin is a new antiepileptic drug. it is used in neurological and psychiatric disorders. moreover the effects of gabapentin on increasing the analgesic effect of morphine and its inhibitory effects on dopamine release due to morphine in animal models have been proved. in the present study, the effect of ...

complexes of the type (och2c(ch3)2ch2ob)2s2p(s)or (where r=me,et,pri,bui,ph,ch2ph) have beensynthesized by the reactions of 2-chloro-1,3,2-dioxaborinanes and potassium salt of o-alkyl (o-aryl)trithiophosphates in 2:1 molar ratio in refluxing benzene. the product are formed as white or light yellowcoloured monomeric solid, soluble in common organic solvents and exhibit high sensitivity towardsat...

background: radiotherapy treatment planning requires different dosimetric quantities as input in order to calculate a desired dose distribution. this study has been focused to evaluate the depth dose characteristics of superficial x-rays being used for radiotherapy treatment. materials and methods: computerized 3-d water phantom of multi-data system was used. the measurements were made through ...

heterocyclic systems are one of the most important classes of organic compounds present in nature or synthesized in laboratory. these compounds posses an array of biological activities and are employed in the treatment of commonly occurring diseases. keeping this in view, some new 2-amino-4,6-diarylpyrimidine from chalcones were synthesized. eight novel 2-amino-4,6-diarylpyrimidine derivatives ...

cyclooxygenase-2 (cox-2) has a pivotal role in the pathogenesis of the lung cancer. it is known that cox-2 negatively regulates the activity of a number of tumor suppressors, including p53. consequently, inhibition of cox-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. in this regard, we investigated the effect of cox-2 signaling blockade on p53 and cox-2 e...

bacteria of the genus azospirillum are well known as plant growth promoting rhizobacteria. the ability to synthesize phytohormones is considered one of the most important mechanisms to promote plant growth and is widely distributed among plant-associated rhizobacteria.the most important phytohormone produced by azospirillum is the auxin indole-3-acetic acid, with the l-tryptophan as the precurs...

abstract background: radiosensitizer drugs are used to enhance the efficiency of radiotherapy. some nanoparticles can be considered as radiosensitizers, because they enhance cytotoxicity due to oxidative stress and increase free radical yield, especially ros , within cells resulting to cell death. methods: in this study, synergistic effect of tio 2 nanoparticles was evaluated in presence of 60 ...