OBJECTIVES To determine the influence of acute ischaemia and absence of leukocytes on the microvascular function and capillary permeability in skeletal muscle. DESIGN Prospective, open study. SETTING University Department of Vascular Surgery and Institute of Medical Physiology. MATERIALS AND METHODS Ten isolated cat gastrocnemius muscles were perfused with oxygen-free Ringer-albumin solut...

in order to increase the water content and the oxygen permeability of hydrogels used in themanufacture of contact lenses, the polar monomer silicon hydrogel contact lenses (shcl), and 2-hydroxyethyl methacrylate (hema) were copolymerized with the hydrogels. due to the presence ofpolar monomers in the conventional contact lenses, the major component of the human tear,lysozyme is extensively adso...

the aim of this study was to investigate the barrier properties of cellulose nanocrystals-pvananocomposites. nanocomposite films with different filler loading levels (3, 6, 9 and 12% by wt) weredeveloped by solvent casting method. the effect of cellulose nanocrystals on the barrier properties ofthe nanocomposites was studied. to this end, moisture absorption, water vapor permeability (wvp),oxyg...

This study demonstrates the changes in six different pathophysiological parameters such as body weight, body temperature, fecal pellet count, blood-brain barrier (BBB) permeability, plasma corticosterone level and emergence of hemorrhagic peptic ulcer spots due to exposure to high environmental heat in three different age groups of freely moving rats. Methods: Each age group of rats was sub di...

polyamide 6 has been widely used in food packaging applications and also green tea contains amounts of antioxidant compounds. the aim of this study was investigation of green tea effects on properties of polyamide packaging polymer. polyamide 6 was dissolved in methanol which was saturated with calcium chloride. the active packaging film was produced by incorporation of methanol green tea extra...

dacarbazine is an antitumor prodrug which is used for the treatment of malignant metastatic melanoma and hodgkin’s disease. it requires initial activation in liver through an n-demethylationreaction. the active metabolite prevents the progress of disease via alkylation of guanine bases in dna strands. in order to investigate the importance of imidazole ring and its dynamictautomerization in ant...

Mitochondria play an important role in cell death and cardioprotection. During ischemia, when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium (Ca(2+)), which further accelerates ATP depletion. The rise in Ca(2+) during ischemia and reperfusion leads to mitochondrial Ca(2+) accumulation, particularly during reperfusion when oxygen is reintroduced. Reintrod...

Using a double-beam stopped-flow apparatus estimations were made of the velocity constant for the initial uptake of oxygen by fully reduced erythrocytes (k'(c)). Mammalian cells were studied with volumes varying from 20 micro(3) (goat) to 90 micro(3) (man), as were bullfrog cells (680 micro(3)). Measurements were made under physiological conditions of pH, P(CO2), and temperature. In man k'(c) w...

Our previous study demonstrated that reactive oxygen species (ROS) released from activated blood cells contribute significantly to the increased microvessel permeability during inflammation. This study aims to define the individual roles of hydrogen peroxide (H(2)O(2)) and superoxide in ROS-induced increases in permeability and endothelial intracellular Ca(2+) concentration ([Ca(2+)](i)) in ind...

Re-expansion pulmonary edema (RPE) is an acute, rare and potentially lethal complication. Its beginning is sudden and dramatic. The mechanism is not yet fully understood. Some authors suggest that it may occur after rapid re-inflation of a collapsed lung. It was reported by other authors that it may relate to surfactant depletion or may result from hypoxic capillary damage, leading to increased...