In the title compound, C29H23N3O4, the 2-methylpyrrolidine ring adopts a twist conformation on the N-C bond involving the spiro C atom, while the hydropyran ring adopts an envelope conformation with the methine C atom bonded to the O atom as the flap. The mean plane of the indoline-2-one ring system is almost perpendicular to the mean plane of the pyrrolidine ring, making a dihedral angle of 89...

Background: Drug repurposing is an alternative strategy to traditional drug discovery that aims at predicting new uses for already existing drugs or clinical candidates. Drug has many advantages over development, such as reduced attrition rates, time and costs. This especially the case considering most investigated have been assessed their safety in trials. Repurposi...

Recently, Moore and co-workers reported the isolation and structural elucidation of several oxindole-containing natural products from blue-green algae. Termed the welwitindolinones, this structurally intriguing class of alkaloids displays diverse and valuable biological properties, including multiple drug resistance (MDR) reversing, insecticidal, and antifungal activities. To date, ten congener...

Cat's claw is an herbal medicine from the Amazon that is used widely to treat inflammatory disorders. The purpose of this study was to characterize the antioxidative and antiinflammatory properties of cat's claw, Uncaria tomentosa (UT) and Uncaria guianensis (UG). Alkaloids and flavanols were determined using reversed-phase HPLC; scavenging of 1,1-diphenyl-2-picrilhydrazyl (DPPH), hydroxyl radi...