for treatment of anti-nutritional factors(anfs), (?-n-oxalyl -l- ?, ? -diaminopropionic acid (?-odap) and condensed tannin (ct)) in grass pea, some such alkali treatments as naoh, nahco3, kmno4 and wood ash, besides water soaking and polyethylene glycol (peg) (6000 mw) were employed . metabolizable energy (me) of treated and of untreated grass pea was assessed using gas production technique, tw...

Structurally different and functionally diverse natural compounds - antitumour agents pyrrolo[1,4]benzodiazepines, bacterial hormone hormaomycin, and lincosamide antibiotic lincomycin - share a common building unit, 4-alkyl-L-proline derivative (APD). APDs arise from L-tyrosine through a special biosynthetic pathway. Its generally accepted scheme, however, did not comply with current state of k...

Epidemics of lathyrism, a neurological syndrome of spastic paraparesis, have occurred during severe droughts in Europe, Asia, and Africa for millenia. Causation is linked to exposure to β-N-oxalyl-L-α,β-diaminopropionic acid (β-L-ODAP), a neurotoxin in Lathyrus sativus. Lathyrism shares neurological features with konzo, a syndrome of predominantly spastic paraparesis which occurs during drought...

3,5-di-tert-butylphenyl morpholin-4-yl ketone. 3,5-di-tert-butylbenzoic acid (7 g, 29.9 mmol) was added to a flame dried flask which had been backfilled with nitrogen three times. DCM (70 mL) was added via canula, followed by DMF (0.77 mL, 9.9 mmol) and oxalyl chloride (2.3 mL, 26.9 mmol) added dropwise over 15 minutes. The mixture was stirred at room temperature for 1 h 30 under a nitrogen atm...

Oxidative stress, excitotoxicity and mitochondrial dysfunction play synergistic roles in neurodegeneration. Maintenance of thiol homeostasis is important for normal mitochondrial function and dysregulation of protein thiol homeostasis by oxidative stress leads to mitochondrial dysfunction and neurodegeneration. We examined the critical roles played by the antioxidant, non-protein thiol, glutath...

Oxalate:ferredoxin oxidoreductase (OOR) is an unusual member of the thiamine pyrophosphate (TPP)-dependent 2-oxoacid:ferredoxin oxidoreductase (OFOR) family in that it catalyzes the coenzyme A (CoA)-independent conversion of oxalate into 2 equivalents of carbon dioxide. This reaction is surprising because binding of CoA to the acyl-TPP intermediate of other OFORs results in formation of a CoA e...