Monoclonal antibodies can bind with high affinity and high selectivity to their targets. As a tool in therapeutics or diagnostics, however, their large size (∼150 kDa) reduces penetration into tissue and prevents passive cellular uptake. To overcome these and other problems, minimized protein scaffolds have been chosen or engineered, with care taken to not compromise binding affinity or specifi...

Disruption of interactions among ensembles of epistatic loci has been shown to contribute to reproductive isolation among various animal and plant species. Under the Bateson-Dobzhansky-Muller model, such interspecific incompatibility arises as a by-product of genetic divergence in each species, and the Orr-Turelli model indicates that the number of loci involved in incompatible interactions may...

In the silkworm, Bombyx mori, normal markings are mainly controlled by the +P gene, which is located on the second chromosome. Due to a lack of crossing over in females, reciprocal backcrossed F1 (BC1) progenies were used for linkage analysis and mapping of the +P gene based on an SSR linkage map using silkworm strains P50 and H9, which are normal marking and sex-limited marking, respectively. ...

This paper establishes new results regarding control problems for parametrized families of pairs ( 'systems') {(A(x), B(x)),xeX}, where A(x) is an n x n and B(x) is an n x m real matrix for each x (with n,m fixed integers), and the parameter x belongs to a manifold X. To be found is a new parametrized family {K(x),x~X} such that a given design criterion is satisfied by the closed-loop matrix A(...

OBJECTIVES To determine patient preferences and cost differences between home-based and hospital-based chemotherapy. DESIGN Randomised crossover trial. SETTING A tertiary cancer hospital in Melbourne, Victoria. PARTICIPANTS 20 patients who required chemotherapy suitable for administration at home. INTERVENTIONS Patients were assigned at random to receive their first chemotherapy treatme...

The accuracy of the SPACETRACK General Perturbations program over short periods is evaluated for a number of cases. They show that oscillatory terms resulting from drag perturbations contribute heavily to errors at low altitudes, and that these terms must be eliminated if the first order theory is to be used for high accuracy in these circumstances. It appears that the evaluation technique empl...

In a previous paper, Bhaduri and Whelan (2008), we presented a simple model of hedge fund liquidity. That paper explored the fact that not being able to pull one’s money out of an investment instantaneously at a fair price can have a powerful impact on the portfolio. Real world examples include the 1993 Metallgesellschaft debacle (Smithson, 1998) and the recent difficulties experienced by the B...

We present an approach to invariant matching. In this approach, an object or a pattern is invariantly represented by an object-centered description called an attributed relational structure (ARS) embedding invariant properties and relations between the primitives of the pattern such as line segments and points. Noise eeect is taken into account such that a scene can consist of noisy sub-parts o...

INCE the original observation of STURTEVANT (1919) a large body of data has accumulated substantiating the contention that, in Drosophila melanogaster females, inversion heterozygosity in one part of the genome increases the frequency of recombination in the remainder of the genome. This effect has been demonstrated for spontaneous meiotic crossing over (see, for instance, SCHULTZ and REDFIELD ...