In this study, it was aimed to determine the allele frequencies and genotype distributions of MTHFR gene C677T and A1298C polymorphisms in a Turkish study population with polycystic ovary syndrome. Genomic DNA was isolated from blood samples of 30 patients with polycystic ovary syndrome and 28 healthy controls. PCR-RFLP technique was used to analyze MTHFR gene C677T and A1298C polymorphisms. Pr...

Polycystic ovary syndrome is the most common form of female infertility in the United States. In addition to poor conception rates, pregnancy loss rates are high (30-50%) during the first trimester. We hypothesized that hyperinsulinemic insulin resistance contributes to early pregnancy loss in the syndrome, and that decreasing hyperinsulinemic insulin resistance with metformin during pregnancy ...

The receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a transmembrane protein belongs to receptor tyrosine kinase (RTK) family. This study aimed to examine the expression of ROR1 in human ovarian cancer and investigate the relationship between its expression and the prognosis of ovarian cancer patients. In this present study, one-step quantitative reverse transcription-polymerase chain ...

Ovarian follicle disruption in mice caused by 7,12-dimethylbenz[a]anthracene (DMBA) is attributed to its bioactivation by CYP1B1 to a 3,4-epoxide which is then hydrolyzed to form a 3,4-diol by microsomal epoxide hydrolase (mEH). Further epoxidation by CYP1A1 or 1B1 forms the ultimate ovotoxicant, DMBA-3,4-diol-1,2-epoxide. Studies suggest that the mouse ovary expresses these enzymes, and thus, ...

BACKGROUND Polycystic ovary syndrome (PCOS) is associated with metabolic abnormalities which are also parts of metabolic syndrome (MetS). It is debated whether all women with PCOS should be screened for MetS and Insulin resistance (IR), since they may vary in terms of PCOS phenotype, ethnicity and age. This large scale study aimed to determine the prevalence of MetS among Iranian women diagnose...

Accessory ovary is a rare gynecologic condition, and tumors arising in accessory ovaries are extremely rare. Accessory ovary may result from separation of migrating ovaries during embryogenesis and injuries such as inflammation and operation on normal ovary. Congenital malformations, most frequently malformations of the genitourinary organ, are seen in connection with the accessory ovary. We ex...

BACKGROUND This study was to investigate the prognostic significance of clinicopathologic characteristics in patients with clear-cell carcinoma (CCC) of the ovary. MATERIALS AND METHODS Two hundred and one patients with CCC of the ovary were registered in the Korean Gynecologic Oncology Group. The Korean Gynecologic Pathology Study Group reviewed the pathological slides centrally, using a uni...

The influence of season on the plasma progesterone concentrations and morphometric values of corpus luteum and ovary was studied through ultrasonography in spring (n=10) and dry hot (n=10) seasons on alternate days during the estrous cycle regardless of estrous phases in Nili-Ravi buffaloes. The mean morphometric values of length and width of ovary and the diameter and area of corpus luteum wer...

BACKGROUND Residual ovarian function after laparoscopic excision of endometriotic ovarian cysts is a major and still unsolved topic. Ultrasonographic evaluation of ovarian response to ovulation stimulation represents a simple yet poorly employed tool to assess residual ovarian function after surgery. METHODS Data from patients referred for IVF or ICSI between January 2001 and December 2002 we...

Introduction: Polycystic ovary syndrome is a complex disorder characterized by elevated androgens, chronic anovulation, and polycystic picture on ultrasound it is one of the most common hormonal disorders, affecting 5%–10% of women of reproductive age. Despite many diagnostic criteria, controversies still exist in definition, evaluation and management of PCOS. Aims and Objective: To investigate...