In the present investigation, vitellogenesis during ovarian development in the freshwater prawn Macrobrachium rosenbergii was assessed. Ovarian development was classified into five stages based on size, colour and texture of ovary. Interestingly, histological results clearly indicate that the oocyte development gradually increased from stages I to V based on the yolk material accumulation. Besi...

Gynaecological endocrinology is concerned with the secretion of hormones by the ovary, the control of ovarian function by the pituitary and the manifestation of ovarian activity by the behaviour of the endometrium and the character and regularity of menstrual bleeding. It is necessary, therefore, to understand the physiology of ovarian hormone secretion, its control and manifestations, the natu...

BACKGROUND The production of ascites is a common complication of ovarian cancer. Ascites constitute a unique tumor microenvironment that may affect disease progression. In this context, we recently showed that ovarian cancer ascites may protect tumor cells from TRAIL-induced apoptosis. In this study, we sought to determine whether the prosurvival effect of ascites affects disease-free intervals...

Ascites from ovarian cancer patients contain potent growth-promoting activity toward human ovarian cancer cells both in vitro and in vivo. This activity is associated with rapid increases in cytosolic free calcium ([Ca2+]i) as a consequence of phosphoinositide hydrolysis. In this study, we describe the purification, characterization, and identification of an ovarian cancer activating factor (OC...

Forty ewes (3-6 years of age, average weight 41.2 kg)were randomly chosen from the flock of the sheep experiment station of Tripoli University. Ewes were divided into two groups, control group (C) received untreated barley straw and treatment group (T) received barley straw treated with 10% urea solution applied as 40% (V/W). Barley straw was sprayed with molasses when fed to animals. Both grou...

Connective tissue components--collagen types I, III and IV--surrounding the ovarian follicles undergo drastic changes during ovulation. Abnormal collagen synthesis and increased volume and density of ovarian stroma characterize the polycystic ovary syndrome (PCOS). During the ovulatory process, collagen synthesis is regulated by prolyl hydroxylase and lysyl oxidase (LOX) activity in ovarian fol...

The mammalian ovary is innervated by sympathetic and sensory neurons which contribute to regulating several aspects of ovarian function, including blood flow, steroidogenesis and follicular development. The existence of a neural connection between central neurons and the ovary has been rarely reported, but the mechanism underlying integration of ovarian activity to broader neuroendocrine respon...

Previously, we showed that basal activity of nitric oxide (NO)/cyclic GMP (cGMP)/protein kinase G (PKG) signaling pathway protects against spontaneous apoptosis and confers resistance to cisplatin-induced apoptosis in human ovarian cancer cells. The present study determines whether basal PKG kinase activity regulates Src family kinase (SFK) activity and proliferation in these cells. PKG-Ialpha ...

Among gynecological malignancies epithelial ovarian cancer (EOC) is the leading cause of death. Despite improvements in conventional chemotherapy combinations, the overall cure rate has remained mostly stable over the years, and only 10%-15% of patients maintain a complete response following first-line therapy. To improve the efficacy of ovarian cancer chemotherapy it is essential to develop dr...

Background Although ovarian tissue cryopreservation and transplantation is used for fertility preservation in patient undergoing cytotoxic treatments but obtaining good quality oocyte is still a debate. Xenotransplantation has been introduced as a reliable technique for better understanding of the transplantation conditions, but to achieve healthy embryos, the quality of obtained oocytes need t...