نتایج جستجو برای: osteocytes

تعداد نتایج: 2034  

2015
Kin-Hing William Lau David J. Baylink Matilda H.-C. Sheng

The present study sought to evaluate the functional role of osteocyte-derived IGF-I in the bone repletion process by determining whether deficient expression of Igf1 in osteocytes would impair the bone repletion response to one week of dietary calcium repletion after two weeks of dietary calcium deprivation. As expected, the two-week dietary calcium depletion led to hypocalcemia, secondary hype...

Journal: :Journal of the Royal Society, Interface 2012
Stefaan W Verbruggen Ted J Vaughan Laoise M McNamara

The osteocyte is believed to act as the main sensor of mechanical stimulus in bone, controlling signalling for bone growth and resorption in response to changes in the mechanical demands placed on our bones throughout life. However, the precise mechanical stimuli that bone cells experience in vivo are not yet fully understood. The objective of this study is to use computational methods to predi...

Journal: :Journal of biomechanics 2016
Chloé Lerebours Pascal R Buenzli

Bone׳s mechanostat theory describes the adaptation of bone tissues to their mechanical environment. Many experiments have investigated and observed such structural adaptation. However, there is still much uncertainty about how to define the reference mechanical state at which bone structure is adapted and stable. Clinical and experimental observations show that this reference state varies both ...

2015
Jun Wang Ali Kalhor Shifeier Lu Ross Crawford Jiang-Dong Ni Yin Xiao

BACKGROUND AND PURPOSE Non-traumatic osteonecrosis is a progressive disease with multiple etiologies. It affects younger individuals more and more, often leading to total hip arthroplasty. We investigated whether there is a correlation between inducible nitric oxide synthase (iNOS) expression and osteocyte apoptosis in non-traumatic osteonecrosis. PATIENTS AND METHODS We collected and studied...

2016
Ahmad Jabir Rahyussalim Tri Kurniawati Nurjati Chairani Siregar Agus Syahrurachman Ismail Hadisubroto Dilogo Diah Iskandriati Arni Diana Fitri

STUDY DESIGN Preliminary experimental study using a rabbit spondylitis model. PURPOSE To observe the ossification in a micro-environment containing live Mycobacterium tuberculosis transplanted with bone marrow stromal cells (BMSCs) in rabbits. OVERVIEW OF LITERATURE BMSCs differentiate to osteoblasts and then osteocytes during ossification. Mycobacterium tuberculosis does not affect BMSC gr...

2011
Takeshi Moriishi Zenjiro Maruyama Ryo Fukuyama Masako Ito Toshihiro Miyazaki Hideki Kitaura Hidetake Ohnishi Tatsuya Furuichi Yosuke Kawai Ritsuko Masuyama Hisato Komori Kenji Takada Hiroshi Kawaguchi Toshihisa Komori

Bcl2 subfamily proteins, including Bcl2 and Bcl-X(L), inhibit apoptosis. As osteoblast apoptosis is in part responsible for osteoporosis in sex steroid deficiency, glucocorticoid excess, and aging, bone loss might be inhibited by the upregulation of Bcl2; however, the effects of Bcl2 overexpression on osteoblast differentiation and bone development and maintenance have not been fully investigat...

Journal: :cell journal 0

objective: osteoblasts arise from multipotent mesenchymal stem cells (mscs) present in the bone marrow stroma and undergo further differentiation to osteocytes or bone cells. many factors such as proteins present in the wnt signaling pathway affect osteoblast differentiation. ror2 is an orphan tyrosine kinase receptor that acts as a co-receptor in the non-canonical wnt signaling pathway. howeve...

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