Knee osteoarthritis (OA) is a painful and incapacitating disease affecting a large portion of the elderly population, for which no cure exists. There is a critical need to enhance our understanding of OA pathogenesis, as a means to improve therapeutic options.Knee OA is a complex disease influenced by many factors, including the loading environment. Analysing knee biomechanics during walking - ...

OBJECTIVE Bone marrow lesions (BMLs) are well described in osteoarthritis (OA) using MRI and are associated with pain, but little is known about their pathological characteristics and gene expression. We evaluated BMLs using novel tissue analysis tools to gain a deeper understanding of their cellular and molecular expression. METHODS We recruited 98 participants, 72 with advanced OA requiring...

Osteoarthritis (OA) is the most prevalent form of arthritis in the elderly. This disease is characterized by breakdown and loss of articular cartilage due to genetic, mechanical and environmental factors. Although the pathophysiology of OA is not completely known, several candidate genes have been reported to be associated with OA susceptibility. We assessed the association between genetic vari...

Osteoarthritis (OA) is the most common form of arthritis in older individuals and is among the most prevalent and disabling chronic conditions worldwide.We conducted a meta-analysis to determine the efficacy and safety of celecoxib, a cyclooxygenase-2 (COX-2) inhibitor in the treatment of osteoarthritis. Studies were pooled, and mean difference (MD), relative risk (RR), and its corresponding 95...

Objective: Osteoarthritis (OA) is a common disease characterized by progressive degeneration of articular cartilage. Several studies have been performed to evaluate the association between asporin gene aspartic acid repeat (ASPN D-Repeat) polymorphism and osteoarthritis susceptibility, but produced conflicting results. Our aim is to determine whether ASPN D-repeat polymorphism is associated wit...

Temporomandibular joint osteoarthritis (TMJ OA) is a common and heterogeneous disease that causes painful and progressive joint degeneration, which restricts daily activities, including talking and chewing. Long noncoding RNAs (lncRNAs) are an important class of genes involved in various physiological and pathological functions, including osteoarthritis (OA).The present study aimed to identify ...

Osteoarthritis Osteoarthritis (OA) is the most common form of arthritis and is among the most prevalent chronic human health disorders in an aging population. It is estimated that over 50% of people aged 65 years and older show radiological signs of OA [1]. This disease mostly affects the hands, hips, knees and spine. The risk factors associated with OA pathophysiology include development-, met...

Predict Pain in Knee Osteoarthritis? 1 Wegrzyn, J; 1 D’Apuzzo, M R; 2 Amrami, K K; 3 Larson, D R; + Kaufman, K R + Motion Analysis Laboratory, Mayo Clinic, Rochester, MN, 2 Radiology, Mayo Clinic, Rochester, MN, 3 Biostatistics, Mayo Clinic, Rochester, MN [email protected] INTRODUCTION: Pain is the major symptom in knee osteoarthritis (OA), contributes to a patients’ reduced function and ...

Introduction: Osteoarthritis (OA) is the most prevalent of all the rheumatic diseases and currently only conventional imaging methods are utilised for diagnosis of OA which only detect the disease at an advance stage where there is already irreparable damage to the joint. Therefore the priority in the field is towards identifying reliable biochemical measures for early diagnosis and prediction ...