We have described clinical features of 53 cases with pustulotic arthro-osteitis. Anterior chest wall symptoms such as intersterno-costoclavicular or manubriosternal lesions were observed in all of 53 cases. Spondylitis or spondylodiscitis was found in 18 cases. Sacroiliitis resembling ankylosing spondylitis was seen in 7 cases. Peripheral inflammatory arthritis was seen in 14 cases, which were ...

Aortic valve (AV) calcification is an inflammation driven process that occurs preferentially in the fibrosa. To explore the underlying mechanisms, we investigated if key microRNAs (miRNA) in the AV are differentially expressed due to disturbed blood flow (oscillatory shear (OS)) experienced by the fibrosa compared to the ventricularis. To identify the miRNAs involved, endothelial-enriched RNA w...

Introduction End-stage renal disease (ESRD) is a life-threatening disease with significant complication and the incidence and prevalence of this disease have signi ficantly increased in recent years and imposes a major social and economic burden for healthcare systems (1,2). As seen worldwide, it is well-established that diabetic nephropathy particularly from type 2 diabetes, and hypertensive n...

The history of the interpretation of osteitis fibrosa cystica generalisata as it was described in 1891 by von Recklinghausen (1) explains why the skeletal abnormalities were for so long considered to be the focal point of the clinical concept "hyperparathyroidism." During the 1930's, however, it was observed that many patients with hyperparathyroidism showed no bone abnormalities on either hist...

Concomitant thyroid disease is not unusual among patients with primary hyperparathyroidism. However, the simultaneous occurrence of parathyroid and thyroid carcinoma is extremely rare. We report a 38-year-old man with primary hyperparathyroidism who presented with osteitis fibrosa cystica complicated with pathologic femoral neck fracture. Preoperative investigation for exclusion of multiple end...

Brown tumor or localized form of osteitis fibrosa cystic is a focal lesion complicating hyperparathyroidism. It’s rarely revelatory of the clinical feature and corresponds to a mass with partly cystic and partly solid areas. A 65-year-old man, followed up for hypertension, complained of a progressive swelling in the left paranasal part of the face lasting for 3 months. Physical examination reve...

To determine (1) the relationship between primary hyperparathyroidism with mild hypercalcemia and psychiatric disturbances, bone density, or non-specific symptoms, and (2) the effect of parathyroidectomy on these outcomes, a systematic and critical review of the literature was conducted. Relevant citations were identified using MEDLINE (1966 to August, 1995) and PsycINFO (1967 to August, 1995)....

The occurrence of more than one giant-cell tumour of bone in the same person (that is, the appearance of the tumour otherwise than as a solitary lesion) is so unusual that one accepts only with great hesitation an apparent instance of this; such a case must be carefully scrutinised to eliminate hyperparathyroidism. Jaffe (1958) observed a case ofgiant-cell tumour involving the lower end of an u...

OBJECTIVE Nowadays, the occurrence of brown tumor lesions or osteitis fibrosa cystica caused by long-lasting primary hyperparathyroidism are very rare, since measuring serum calcium became available routinely in the mid-1970s. It is a tumor-like lesion that may affect the entire skeleton, often presenting with diffuse focal bone pain or by pathological fracture. METHODS We describe our experi...