Purpose: This phase II study was conducted to assess the efficacy of temozolomide in patients with relapsed small cell lung cancer (SCLC). Experimental Design: Patients with disease progression after one or two prior chemotherapy regimens received temozolomide at 75 mg/m/d for 21 days of a 28-day cycle. The primary endpoint was the overall response rate [ORR; complete response (CR) plus partial...

The electrocatalytic oxygen reduction reaction (ORR) on nanoparticles has attracted much attention in recent years for its significance in fuel cell applications. Here by combining density functional theory (DFT) calculations with the periodic continuum solvation model based on modified-Poisson-Boltzmann (CM-MPB) electrostatics, we analyzed the ORR activity on a set of differently sized Pt nano...

Efficient reduction of O2 to water is a central challenge in energy conversion and many aerobic oxidation reactions. Here, we show that the electrochemical oxygen reduction reaction (ORR) can be achieved at high potentials by using soluble organic nitroxyl and nitrogen oxide (NO x ) mediators. When used alone, neither organic nitroxyls, such as 2,2,6,6-tetramethyl-1-piperidinyl-N-oxyl (TEMPO), ...

PURPOSE This phase II study was conducted to assess the efficacy of temozolomide in patients with relapsed small cell lung cancer (SCLC). EXPERIMENTAL DESIGN Patients with disease progression after one or two prior chemotherapy regimens received temozolomide at 75 mg/m(2)/d for 21 days of a 28-day cycle. The primary endpoint was the overall response rate [ORR; complete response (CR) plus part...

Development of a highly durable, fuel-tolerant, metal-free electro-catalyst for oxygen reduction reaction (ORR) is essential for robust and cost-effective Anion Exchange Membrane Fuel Cells (AEMFCs). Herein, we report the development of a nitrogen-doped (N-doped) hierarchically porous carbon-based efficient ORR electrocatalyst from protein-rich pulses. The process involves 3D silica nanoparticl...

The availability of low-cost, efficient, and durable catalysts for oxygen reduction reaction (ORR) is a prerequisite for commercialization of the fuel cell technology. Along with intensive research efforts of more than half a century in developing nonprecious metal catalysts (NPMCs) to replace the expensive and scarce platinum-based catalysts, a new class of carbon-based, low-cost, metal-free O...

This paper continues the study of decompositions of a smooth 4-manifold into two handlebodies with handles of index ≤ 2. Part I gave existence results in terms of spines and chain complexes over the fundamental group of the ambient manifold. Here we exploit the fact that one side of a decomposition frequently has larger fundamental group to define algebraic-topological invariants. The main theo...

Catalysts for oxygen reduction reaction (ORR) are at the heart of key green-energy fuel cell technology. N-doped graphene is a potential metal-free electrode with much better electrocatalytic activity, long-term stability, and tolerance to crossover effect than expensive platinum-based electrocatalysts. Here, we report a feasible direct-synthesis method in preparing N-graphene with manageable N...

By varying the external electric field in density functional theory (DFT) calculations we have estimated the impact of the local electric field in the electric double layer on the oxygen reduction reaction (ORR). Potentially, including the local electric field could change adsorption energies and barriers substantially, thereby affecting the reaction mechanism predicted for ORR on different met...

Volume 5, no. 34, e00884-17, 2017, https://doi.org/10.1128/genomeA.00884-17. Page 2: Reference 5 should read as follows. 5. Warren RL, Yang C, Vandervalk BP, Behsaz B, Lagman A, Jones SJ, Birol I. 2015. LINKS: scalable, alignment-free scaffolding of draft genomes with long reads. Gigascience 4:35. https://doi.org/10.1186/s13742-015-0076-3. Published 5 October 2017 Citation Orr RJS, Rombauts S, ...