Background: The pomegranate peel extract is a rich source of natural antioxidant and antimicrobial activity. The aim of the present investigation was to evaluate the in vivo antifungal activity of the pomegranate peel extract and to compare it with nystatin against oral candidiasis in Wistar rats.Methods: Thirty-five male Wistar rats, 6 to 8 weeks old and 220 to 250 g in weight, were used for a...

candidiasis is one of the commonest causes of vaginitis.different treatment have been suggested for this disease.oral  itraconazole is one of the newest medications.to evaluate the antifungal activity of this drug in vaginal candidiasis,this study was performed on a random sample of patients.fifty patients with vaginal candidiasis confirmed by direct examination and culture,were treated by a si...

The disproportionate increase in oropharyngeal candidiasis (OPC) compared with systemic and vaginal candidiasis in female patients with AIDS has been a paradox for almost three decades. New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease. These findings clarify and extend our cur...

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare disorder caused by mutations in the autoimmune regulator (AIRE) gene, leading to defects in T cell selection. The disease manifestations include both autoimmune tissue destruction and immunodeficiency, with specific susceptibility to chronic mucocutaneous candidiasis. Studies have demonstrated a wide repertoire of...

The most common nosocomial fungal infection in hospitals is urinary tract candidiasis. Candida albicans the prevalent cause of infections, however species distribution changing rapidly. At same time, rise candidiasis has resulted emergence antifungal-resistant species. This study aimed to diagnose Spp. In women with UTI and reveal nucleotides sequences CA-INT-L Gene look for mutation within gen...

background vulvovaginal candidiasis (vvc) is a fungal infection of the vagina and vulva. it is usually caused by candida albicans, however, occasionally other candida species are responsible. the optimal treatment of vvc has not yet been defined. the present study was designed to compare the efficacy and safety of a single oral dose of fluconazole with clotrimazole vaginal cream as the treatmen...

Background: Invasive candidiasis infection is one of the main life-threatening problems for extremely low birth weight (ELBW) neonates who are in the neonatal intensive care unit (NICU). Candidiasis can cause mortality, short-term morbidity, and long-term neurodevelopmental outcome in infected infants who survive. Therefore, since several years ago fluconazole prophylaxis has begun for prematur...

Introduction: Mannan is a major component of the Candida albicans cell wall, composing up to 7% of the cell dry weight, and is one of the main Candida antigens that circulate during infection. It is a serum marker for the presence of Invasive Candidiasis is Candida Mannan antibody, which has been included in the relevant European Organization for Research and Treatment of Cancer/ Mycoses Study ...