The classification of rhythmic licking into clusters has proved to be useful for characterizing brain mechanisms that modulate the ingestion of natural rewards (sucrose and water). One cortical area that is responsive to rewarding stimuli is the orbitofrontal cortex (OFC). However, it is not presently known how OFC neurons respond while rodents freely lick for natural rewards and whether these ...

Optimal feedback control (OFC) provides a powerful tool to interpret voluntary motor control, highlighting the importance of sensory feedback in the control and planning of movement. Recent studies in the context of OFC have increasingly used mechanical perturbations and visual shifts to probe voluntary control processes. These studies reveal the surprising sophistication of corrective response...

One hundred and seventy two healthy term (T) appropriate-for-dates (AFD) singleton neonates were prospectively studied from birth until 28 days of age for changes in weight, occipitofrontal circumference (OFC), chest circumference (CC), midarm circumference (MAC), thigh circumference (TC) and crownheel length (CHL). Male babies had statistically significant (p < 0.05) higher values than females...

Rare mutations in IRF6 and GRHL3 cause Van der Woude syndrome, an autosomal dominant orofacial clefting disorder. Common variants in IRF6 and GRHL3 also contribute risk for isolated orofacial clefting. Similarly, variants within genes that encode receptor tyrosine kinase (RTK) signaling components, including members of the FGF pathway, EPHA3 and SPRY2, also contribute risk for isolated orofacia...

The orbitofrontal cortex (OFC) has been described as signaling outcome expectancies or value. Evidence for the latter comes from the studies showing that neural signals in the OFC correlate with value across features. Yet features can co-vary with value, and individual units may participate in multiple ensembles coding different features. Here we used unblocking to test whether OFC neurons woul...

BACKGROUND Surgical correction of orofacial clefts greatly mitigates negative outcomes. However, access to reconstructive surgery is limited in developing countries. The present study reviews epidemiological data from a single charitable organization, Smile Train, with a database of surgical cases from 33 African countries from 2001-2011. METHODS Demographic and clinical patient data were col...

Ardinger et al. (1989) hypothesized that there might be a nonrandom association between clefting and RFLPs of candidate genes which have a role in palate formation. They reported a significant association between two RFLPs of transforming growth-factor alpha (TGFa) and clefting in a group of 80 patients with nonsyndromic cleft lip with or without cleft palate (CLIP) and in a group of 102 contro...

The aim of this prospective study is to determine the incidences of cleft lip and palate in Karnataka & Kerala population. It also highlights a part of embryological aspect and theories that help to correlate and understand the incidence of the congenital anomaly. This prospective study were conducted in 1000 patients having cleft lip and palate deformities and classified, incidences and types ...

Objectives of the Study. Cleft lip and palate (CLP) is a prevalent congenital anomaly in the orofacial region. Autogenous iliac bone grafting has been frequently employed for the closure of bone defects at the jaw cleft site. Since the related surgical procedures are quite invasive for patients, it is of great importance to develop a new less invasive technique. The aim of this study was to exa...

Context: Cleft Lip and Palate (CL/P) is the most common craniofacial malformation in oral cavity, with a prevalence of “1 to 2in 1,000 live births worldwide. Parents CL/P children are more prone experience emotional disorders, especially depression, have higher child-related stress than parents normal children. Due effect mental status on children, assessment psychological aspects this problem ...