Nigella sativa (family Ranunculaceae) is an annual plant that has been traditionally used on the Indian subcontinent and in Middle Eastern countries. In this study, we investigated the effect of N. sativa oil on the drug-metabolizing cytochrome P450 (CYP) enzymes and whether it has a protective effect against the acute hepatotoxicity of CCl4. Intraperitoneal injection of rats with CCl4 drastica...

BACKGROUND In the present study the effect of Nigella sativa (N. sativa) ethanolic extract on cytokine profile in control, moderate and overtrained heavy exercised rat was examined. METHODS Male Wistar rats were randomly divided into control sedentary (C), moderate trained (MT), (V = 20 m/min, 30 min/day, 6 days a week, for 8 weeks), overtrained (OT) (V = 25 m/min, 60 min/day, 6 days a week, ...

OBJECTIVES Nigella sativa (N. sativa) is an amazing herb which is used in traditional medicine for a wide range of illnesses including bronchial asthma, dysentery, gastrointestinal problems, as well as beneficial effect on blood lipids, lowering blood pressure, serum cholesterol, and triglycerides level. This study aimed to determine the toxic effect of N. sativa powder on the kidney function w...

Introduction: Amphotericin B is considered as one of the most effective antifungal drugs presently used to treat systemic fungal infections; however, nephrotoxicity remains the major side effect. The current study is therefore, designed to determine Amphotericin B induced nephrotoxicity and its prevention by administration of Nigella sativa (NS) extract in albino mice. Materials and Methods: Th...

OBJECTIVE Inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. Curcuma longa (C. longa) and Nigella sativa (N. sativa) have anti-inflammatory and antioxidant effects. This study was designed to investigate the effect of mixed hydro-alcoholic extract of N.sativa and C. longa on the oxidative stress induced by Adriamycin (ADR) in rat kidney. MATERI...

OBJECTIVES There are several scolicidal agents for inactivation of hydatid cyst protoscolices during surgery, but most of them are associated with adverse side effects such as sclerosing cholangitis and liver necrosis. The present study was aimed to evaluate scolicidal effects of various extracts of Nigella sativa seeds against protoscoleces of hydatid cyst in an in vitro model. MATERIALS AND...

Nigella sativa Linn. (Ranunculaceae) (N. sativa), commonly known as black seed or black cumin, is an herbaceous plant, mainly grows in the Middle East, Central Europe and Western Asia. It is widely used in indigenous system of medicine for treatment of numerous disorders for over 2 000 years[1-3]. Its seed oil had been widely used in Arab traditional of medicine for the treatment of arthritis, ...

We have been conducting research on the beneficial effects of Nigella sativa for more than 15 years. We have conducted several clinical trials and used up to 3 g/d and found no toxic effect, rather N. sativa had positive effects on these patients. N. sativa in three doses (1, 2, and 3 g/d) with 40 mg nexium produced from 50% to 67% eradication of Helicobacter pylori in non-ulcer dyspeptic patie...

OBJECTIVE The possible toxicity of drugs in pregnancy should be tested before their use in pregnant patients. In the present study, we aimed to evaluate the safety of phytovagex, a pessary formulation of Nigella sativa (N. sativa), which is already in clinical use for vaginal fungal infection. MATERIALS AND METHODS The pregnant rats were treated intravaginal with physiological saline (vehicle...

OBJECTIVE The aim of this study was to elucidate the mechanism(s) responsible for the vasorelaxant effect of Nigella sativa (N. sativa). METHODS The activity of different concentrations of N. sativa extract was evaluated on contractile responses of isolated aorta to KCl and phenylephrine (PE). RESULTS The extract (2-14 mg/mL) induced a concentration dependent relaxation both in endothelium-...