نتایج جستجو برای: organometallic compound
تعداد نتایج: 131105 فیلتر نتایج به سال:
Unlike other tumors, melanomas harbor wild-type (WT) p53 but exhibit impaired p53-dependent apoptosis. The mechanisms for the impaired p53 activation are poorly understood but may be linked to the high expression of the p53 suppressor Mdm2, which is found in >50% of melanoma lesions. Here, we describe an organometallic glycogen synthase kinase 3beta (GSK3beta) inhibitor (DW1/2) as a potent acti...
Novel permethylated pentalenide anions are reported which offer exciting new opportunities for the future development of organometallic pentalene chemistry.
The application of organoaluminium compounds as components of organometallic or complex systems is connected with a knowledge of their reactions with electron donors. Reactions with nitriles, ketones, esters, ethers, alkyl chlorides, vinyl chloride, and acid chlorides as the electron donors were investigated. The first stage of the reaction of an organoaluminium compound with an electron donor ...
New organometallic gold(III) and platinum(II) complexes containing iminophosphorane ligands are described. Most of them are more cytotoxic to a number of human cancer cell lines than cisplatin. Cationic Pt(II) derivatives 4 and 5, which differ only in the anion, Hg2Cl6(2-) or PF6(-) respectively, display almost identical IC50 values in the sub-micromolar range (25-335-fold more active than cisp...
My research interests concern mainly the study of the modes of action of metal compounds as anticancer agents and the development of novel metal-based chemical entities with possible biological applications. Besides synthetic inorganic chemistry and structural characterization of new metal complexes (mainly gold coordination and organometallic compounds), we strongly focus on an intensive biolo...
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