Sepsis remains a major global healthcare problem, indicate as most frequently cause of morbidity and mortality worldwide. The last consensus sepsis in 2016 defined life threatening organ dysfunction caused by dysregulated host response to infection. Dysfunction organs can be represented Sequential [Sepsis-Related] Organ Failure Assessment (SOFA) score. Score2 points or more consequent the Nowad...

Humans eating diets deficient in the essential nutrient choline can develop organ dysfunction. We hypothesized that common single nucleotide polymorphisms (SNPs) in genes involved in choline metabolism influence the dietary requirement of this nutrient. Fifty-seven humans were fed a low choline diet until they developed organ dysfunction or for up to 42 days. We tested DNA SNPs for allelic asso...

OBJECTIVE To investigate the alterations in circulating pro-inflammatory cytokines and cytokine production by peritoneal macrophages during the development of multiple organ dysfunction syndrome. DESIGN Prospective, controlled laboratory study on zymosan-induced generalized inflammation in mice. Single intraperitoneal administration of zymosan induces, over a 12-day period, a triphasic illnes...

Background: Pediatric logistic organ dysfunction (PELOD) score, which can predict mortality or multiple organ dysfunction syndrome (MODS) outcomes, has been validated for children. It is cumbersome to measure respiratory dysfunction variables included in original PELOD scoring, in ventilator and blood gas analysis limited setups, so all three variables included under respiratory dysfunction (i....

In non-immune individuals, early diagnosis and treatment with appropriate antimalarials lead to recovery within few days. On the contrary, a late diagnosis and/or delayed therapy may lead to the development of various complications causing death. At present, complicated malaria is no more limited to anaemia, cerebral malaria or renal failure. Though it is conventional to describe various compli...

BACKGROUND Cell-free DNA concentrations increase in the circulation of patients after trauma and may have prognostic potential, but little is know concerning the temporal changes or clearance of the DNA or its relationships with posttraumatic complications. We investigated temporal changes in plasma DNA concentrations in patients after trauma with use of real-time quantitative PCR. METHODS Se...

BACKGROUND Selenium plays an important role in defence against acute illness. We investigated, in intensive care unit (ICU) patients, the time course of plasma selenium concentrations and their relationship to systemic inflammatory response syndrome (SIRS), organ dysfunction/failure, infection, and ICU outcome. METHODS Plasma selenium and laboratory indices of organ dysfunction/failure, tissu...

Here we review the recent literature on pelvic floor dysfunction, which is increasingly common in women of reproductive age and represents a significant medical problem occurring as result injured ligaments. Pelvic dysfunction largely associated with vaginal delivery might lead to urinary fecal incontinence well organ prolapse. Intraabdominal hypertension, nerve damage, obesity, genetic predisp...