PURPOSE To assess changes in oral cavity (OC) shapes and radiation doses to tongue with different tongue positions during intensity-modulated radiation therapy (IMRT) in patients with head and neck squamous cell carcinoma (HNSCC) but who refused or did not tolerate an intraoral device (IOD), such as bite block, tongue blade, or mouthpiece. RESULTS Tongue volume outside of OC was 7.1 ± 3.8 cm3...

BACKGROUND Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer diagnosed within the oral cavity worldwide. Many studies in India report OTSCC ranking among the top two most common subsites within the oral cavity. India is often labeled the oral cancer capital of the world. The incidence of tongue cancers in the population-based cancer registry (PBCR) of Chennai is showing an i...

R-Spondin1 (RSpo1) is a novel secreted protein that augments canonical Wnt/ -catenin signaling. We injected recombinant RSpo1 protein into transgenic Wnt reporter TOPGAL mice and have identified the oral mucosa as a target tissue for RSpo1. Administration of RSpo1 into normal mice triggered nuclear translocation of -catenin and resulted in increased basal layer cellularity, thickened mucosa, an...

UNLABELLED Lipomas are the most common benign soft tissue mesenchymal tumours composed of mature adipose tissue. They are uncommon in the oral and maxillofacial regions, with 15-20 % of cases involving the head and neck region and less than 5% of all benign oral lesions. Multiple symmetric lipomatosis is rare and characterized by diffuse growth and nonencapsulated lipomas. It is usually found i...

R-Spondin1 (RSpo1) is a novel secreted protein that augments canonical Wnt/beta-catenin signaling. We injected recombinant RSpo1 protein into transgenic Wnt reporter TOPGAL mice and have identified the oral mucosa as a target tissue for RSpo1. Administration of RSpo1 into normal mice triggered nuclear translocation of beta-catenin and resulted in increased basal layer cellularity, thickened muc...

BACKGROUND AND PURPOSE Several studies indicated that tumor thickness or tumor volume might be helpful predictors for the prognosis of oral tongue squamous cell carcinoma. Our aim was to compare the value of tumor thickness versus tumor volume measurement based on preoperative MR imaging in predicting the prognosis of oral tongue squamous cell carcinoma, especially focusing on lymph node metast...

introduction: according to the prevalence of sore mouth, its outcome and possible role of anemia in its etiology and some contradictions in this theory, our study was performed to evaluate the role of iron deficiency anemia as a etiological factor for sore mouth. materials and methods: this historical cohort study was performed on 40 cases, including 20 anemic patients as the experimental group...

Oral malodor or halitosis is any unpleasant odor emerging from the mouth that is detected by others. Many patients experience extreme discomfort and embarrassment and therefore seek help for this problem. Oral causes, such as poor oral hygiene, periodontal disease, tongue coating, food impaction, unclean dentures, faulty restorations, and dry mouth, are far more common than nonoral causes of ma...

This study aimed to evaluate the prevalence and factors associated with oral mucosa alterations in patients from Vale do Jequiti-nhonha, Brazil. The sample consisted of 511 patients of both genders. Questionnaires were used to obtain information about patient gender, age, race, systemic disease state, medication use, cigarette use and alcohol consumption. Physical examinations were then perform...