In the present study, Saccharopolyspora erythraea MTCC 1103 was used for the enhanced production of erythromycin. To enhance the yield of erythromycin, effects of various parameters such as bagasse concentration, organic nitrogen source, inorganic nitrogen source, pH and temperature were analysed. It was found that bagasse can be used as an alternate carbon source in erythromycin production med...

BACKGROUND Erythromycin is recommended for secondary prophylaxis in children with rheumatic heart disease, who are allergic to penicillin. CASE CHARACTERISTICS A 9-year-old girl, with rheumatic heart disease, on secondary prophylaxis with erythromycin 250 mg BD, presented with acute rheumatic fever. OUTCOME Responded to steroids and started on a higher dose (250 mg TDS) of erythromycin for ...

Erythromycin was recovered in high yield after incubation with gram-negative bacteria. The cell-free protein-synthesizing preparation from gram-negative bacteria is equally as susceptible to the antibiotic as is that from gram-positive bacteria. Thus, neither destruction of erythromycin nor the absence of the step susceptible to the antibiotic plays an important role in the resistance mechanism...

neonatal conjunctivitis (ophthalmia neona-tarum) continues to involve many neonates in areas with no eye prophylaxis. povidone iodine solution is an effective antimicrobial agent with broad antibacterial and antiviral activity and it is less expensive and less toxic than the other agents. it seems to be a good alternative for routine eye prophylaxis, especially in developing countries. in a pro...

A liquid chromatographic method was developed and validated for the determination of erythromycin an oxime and related substances. The chromatographic analysis was performed on Inertsil C18 ODS column, using the phosphate buffer solution (0.02 M, pH 6.5)-acetonitrile (40:60, V/V) as the mobile phase. Wavelength of the UV detector was 215 nm. All four related substances, including Z isomer of er...

The commonly accepted biosynthetic pathway1) leading to erythromycin A (I) requires that substrate for sugars (L-mycarose and Ddesosamine) attachment should be erythronolide B (IV). Once both sugars are linked to the aglycone, giving rise to erythromycin D, C-12 hydroxylation would occur resulting in erythromycin C production. Erythromycin C is further converted to erythromycin A by O-methylati...

CONTEXT Household contacts of patients with pertussis are at increased risk of acquiring infection. Chemoprophylaxis has been recommended to decrease transmission, particularly to young infants who are at increased risk of severe disease. Although epidemiologic investigations of outbreaks have suggested a benefit, there have been no prospective studies evaluating the efficacy of chemoprophylaxi...