Ribonucleotide reductases catalyze a key step in DNA biosynthesis, using a diverse array of unprecedented metallo-cofactors to generate a transient protein radical that initiates nucleotide reduction. The new understanding of the chemistry and biochemistry of the system has allowed rational design of inhibitors of this process, which function as antitumor and antiviral agents.

This chapter presents an approach for target behavior tendency estimation (Receding, Approaching). It is developed on the principles of DezertSmarandache theory (DSmT) of plausible and paradoxical reasoning applied to conventional sonar amplitude measurements, which serve as an evidence for corresponding decision-making procedures. In some real world situations it is difficult to finalize these...

This study assessed the effects of natural expressive tendencies on physiological response to stress. Male undergraduates were unobtrusively observed while watching a stressor videotape. On the basis of the subjects' facial responsiveness to the film, a group of 23 natural expressers and 22 natural inhibitors were selected and exposed to a threat of shock situation during which heart rate, resp...

The treatment of HIV infection in Latvia by using highly active antiretroviral therapy (HAART) was started in 1996. The prevalence and tendencies of HIV drug resistance among treated and treatment-naive patients in Latvia in the years 2006-2007 were evaluated in this study. Data of HIV genotyping, performed in 132 HIV-1 infected during years 2006-2007 by TRUGENE HIV-1 genotyping assay (BayerHea...