Changes in dynamic properties of structures indicate occurrence of damages in the structures. In this paper, a new two stage algorithm for damage detection of large structure is introduced. A modified Residual Force Method is utilized to locate the damage regions in structures, especially barrel vaults, and then the enhanced Charged System Search (CSS) Algorithm is used to quantify the amount o...

Vault particles are naturally occurring proteinaceous cages with promising application as molecular containers. The use of vaults as functional transporters requires a profound understanding of their structural stability to guarantee the protection and controlled payload delivery. Previous results performed with bulk techniques or at non-physiological conditions have suggested pH as a parameter...

Oxygen molecule modulates tumour response to radiotherapy. Higher radiation doses are required under hypoxic conditions to induce cell death. Hypoxia may inhibit the non-homologous end-joining DNA repair through down regulating Ku70/80 expression. Hypoxia induces drug resistance in clinical tumours, although the mechanism is not clearly elucidated. Vaults are ribonucleoprotein particles with a ...

In the present paper the concept of uncertain resources in experimental design is extended to situations in which the desire for additional information increases with the amount of experiments available. For a number of simple but relevant examples diierent strategies are compared and optimal designs are developed in the scope of the theory of generalized designs.

The present paper refers to our study on reducing friction reciprocating sliding surfaces by surface texturing. purpose of this is develop optimal design guidelines for texturing clarifying its effect the lubrication characteristics under various operating conditions. Numerical analysis has been performed solving Reynolds equation using finite element method evaluate texturing．The major results...

Permanent magnet synchronous generators (PMSG) have a huge potential for direct-drive wind power applications. Therefore, optimal design of these generators is necessary to maximize their efficiency and to reduce their manufacturing cost and total volume. In this paper, an optimal design of a six-phase 3.5 KW direct-drive PMSG to generate electricity for domestic needs is performed. The aim of ...

the objective of the current study was to develop and optimize a sublingual tablet formulation of captopril which is an effective drug in the treatment of hypertension. captopril containing tablets were prepared by direct compression method using different ingredients such as polyvinyl pyrrolidone, starch 1500, sodium starch glycolate and lactose (independent variables) and magnesium stearate, ...