OBJECTIVE To calculate the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of measurements of the retinal nerve fiber layer using the Stratus optical coherence tomography in glaucoma subjects with visual field defects on achromatic perimetry as the gold standard. STUDY DESIGN Comparative cross-sectional. PLACE AND DURATION OF STUDY Outd...

Purpose. Buried disc drusen are an important differential diagnosis for papilledema. Spectral domain optical coherence tomography (SD-OCT) affords clinicians with new non-invasive opportunities to probe below the surface of the optic nerve. Clinicians may use the knowledge of this appearance to rule out buried disc drusen in patients with irregular optic nerve borders or a bulging, hyperemic ap...

A novel method for damage-free, artifact-free stimulation of neural tissue using pulsed, low-energy infrared laser light is presented. Optical stimulation elicits compound nerve and muscle potentials similar to responses obtained with conventional electrical neural stimulation in a rat sciatic nerve model. Stimulation and damage thresholds were determined as a function of wavelength using a tun...

A variety of biochemical and biophysical cues have been investigated with the goal of promoting regenerative ability of peripheral nerves. Among those neurotrophic factors, topography, and electrical stimulation have been proposed to enhance nerve growth. This thesis explores optogenetic neural stimulation as a means to control neurite growth that promises greater cell-type specificity than com...

Submit Manuscript | http://medcraveonline.com Abbreviations: CS: Contrast Sensitivity; MS: Multiple Sclerosis; ANN: Artificial Neural Network; CNS: Central Nervous System; ON: Optic Neuritis; OCT: Optical Coherence Tomography; VA: Visual Acuity; CSF: Contrast Sensitivity Function; CG: Control Group; ONH: Optic Nerve Head; GCC: Ganglion Cell Complex; FLAIR: Fluid Acquisition Inversion Recovery; ...

Neurotransmitter-containing vesicles in presynaptic nerve terminals are essential for synaptic transmission. The vesicles undergo a cycle that leads to transmitter release by exocytosis followed by endocytosis and refilling of the vesicles. Here we discuss new optical methods that have helped researchers study this cycle at functional and molecular levels, which is essential for our understandi...

PURPOSE To present a new retinal layer segmentation technique for evaluation of nerve fiber hyperplasia in patients with autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). METHODS Five patients with a molecular diagnosis of ARSACS and five age- and sex-matched healthy controls underwent a full ophthalmologic examination, which included a new technique to segment the retinal l...

conclusions complete rupture of the facial nerve is challenging and the treatment is surgery, which requires careful planning. introduction facial paralysis is a devastating condition with profound functional, aesthetic and psychosocial consequences. tumors within or outside the skull, bell’s palsy and trauma are the most common causes of facial paralysis in adults. case presentation our patien...