RATIONALE Visual impairment is one of the most common clinical manifestations of multiple sclerosis (MS). Some multiple sclerosis patients complain of poor vision although the Snellen visual acuity is 20/20. This study reveals that sensitive measurements like visual evoked potential (VEP) and optical coherence tomography (OCT) can evidence subclinical disturbances of visual pathway. These metho...

Optical Coherence Tomography (OCT) is an emerging optical imaging technology with ever growing number of applications. OCT enables micron scale cross-sectional imaging of subsurface microstructures by measuring the backscattered intensity of light from subsurface layers of the materials. Current OCT imaging systems are fiber or free space optics based and they can be miniaturized through integr...

Optical coherence tomography (OCT) has become pivotal in the practice of ophthalmology. Similar to other ophthalmic subspecialties, ophthalmic oncology has also incorporated OCT into practice. Anterior segment OCT (AS-OCT), ultra-high resolution OCT (UHR-OCT), spectral domain OCT (SD-OCT) and enhanced depth imaging OCT (EDI-OCT), have all been described to be helpful in the diagnosis, treatment...

1.1 Overview of optical coherence tomography Optical coherence tomography (OCT) is a promising imaging technology which can provide subsurface imaging of biological tissues (Huang et al., 1991). OCT images are similar to the ultrasound images, but with significantly higher resolution (5-10 times) than the clinical ultrasound. OCT enables imaging of tissue microstructure with micron-level resolu...

PURPOSE To demonstrate the use of phase-variance optical coherence tomography (PV-OCT) angiography for detection of pigment epithelial detachment (PED) vascularization in age-related macular degeneration (AMD). PATIENTS AND METHODS Patients with PEDs and exudative AMD were evaluated by the Retina Services at the University of California, Davis, and the University of California, San Francisco....

PURPOSE To determine peripapillary retinal nerve fiber layer (RNFL) thickness values by three-dimensional optical coherence tomography (3D-OCT) in a normal Iranian population and to evaluate the concordance of these measurements with those obtained by the second generation of optical coherence tomography (OCT II). METHODS In a cross-sectional observational study, 96 normal Iranian subjects 20...

The continuing improvement of high-speed area-scan cameras has made possible the construction of parallel optical coherence tomography (OCT) systems that are competitive with the fastest demonstrated swept-source OCT systems. Unfortunately, when imaging through turbid media using a partially coherent source, parallel OCT suffers resolution loss from coherent multiple scattering, a phenomenon kn...

Speckle in optical coherence tomography (OCT) images originates in the high spatial coherence of incident light that enables interference of light backscattered from spatially heterogenous tissue specimens. We report results of a numerical simulation and an experiment to test speckle reduction using a partially spatially coherent source. A Gaussian-Schell model for a partially spatially coheren...

Optical coherence tomography (OCT) is a non-invasive micrometer-resolution volumetric imaging modality that has been employed in diverse applications. In this thesis, we first describe a GPU accelerated program to perform FDOCT data processing and real time 3D volumetric rendering. The real time visualization of volumetric images provided by the GPU acceleration was essential to the rest of the...

purpose : to compare the ability of scanning laser polarimetry (gdx vcc), and optical coherence tomography (oct) to discriminate eyes with primary open angle glaucoma (poag) from normal eyes and to assess the relationship between their parameters methods : eighty-seven glaucomatous eyes of 87 patients and 25 normal eyes were enrolled. the mean age of patients and normal group were 54.96±18.34 a...