نتایج جستجو برای: opiate system

تعداد نتایج: 2234993  

Journal: :Psychiatria Danubina 2017
Diana Raketic Jasmina V Barisic Snezana M Svetozarevic Tatjana Gazibara Darija Kisic Tepavcevic Srdjan D Milovanovic

BACKGROUND The prevalence of female alcohol and substance abusers has markedly increased. The main objective of this research was to explore personality profiles among females who had alcohol and opiate dependence. AIM The aim of the study is to analyse if there is differences in personality profiles of females addicted to alcohol and opiates. We hypothesized that there might be significant d...

Journal: :The Journal of pharmacology and experimental therapeutics 2000
J P Druhan C L Walters G Aston-Jones

Withdrawal is a potent motivator of drug-seeking behavior in human opiate addicts. Paradoxically, opiate withdrawal reduces dopamine release and suppresses behavioral responding in several animal models of addiction. These findings pose critical questions about how a withdrawal state that depresses dopaminergic and behavioral functioning contributes to drug seeking. This study addressed this is...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Tasha Ahmad Nicole M Lauzon Xavier de Jaeger Steven R Laviolette

Cannabinoid, dopamine (DA), and opiate receptor pathways play integrative roles in emotional learning, associative memory, and sensory perception. Modulation of cannabinoid CB1 receptor transmission within the medial prefrontal cortex (mPFC) regulates the emotional valence of both rewarding and aversive experiences. Furthermore, CB1 receptor substrates functionally interact with opiate-related ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1973
C B Pert S H Snyder

[(3)H]Naloxone, a potent opiate antagonist, binds stereospecifically to opiate-receptor sites in rat-brain tissue. The binding is time, temperature, and pH dependent and saturable with respect to [(3)H]naloxone and tissue concentration. The [(3)H]naloxone-receptor complex formation is bimolecular with a dissociation constant of 20 nM. 15 Opiate agonists and antagonists compete for the same rece...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1977
A J Blume J Shorr J P Finberg S Spector

The endogenous central nervous tissue substance called MLC (morphine-like compound) is shown to bind to the opiate receptors of the mouse neuroblastoma X glioma hybrid cell line NG108-15. The interaction of MLC with these opiate receptors is noncooperative, as is the interaction of morphine, naloxone, and Leu-enkephalin with these receptors. A specific antibody to morphine will bind MLC but wil...

Journal: :Hypertension 1981
J E Szilagyi C M Ferrario

Angiotensin II, when given into the vertebral arteries, acts at the area postrema to augment central sympathetic vasomotor activity. The mechanism of action is unknown but recent evidence implicates an interaction with the opiate system. In dogs anesthetized with chloralose either alone or in combination with morphine, naloxone blunted the pressor response to vertebrally administered angiotensi...

2015
Mary Cheung Sundas Khan Meredith Akerman Chun Kit Hung Kaitlyn Vennard Nicholas Hristis Keith Sultan

BACKGROUND The safety of opiate use for patients with Crohn's disease (CD) has long been a concern. The recent Crohn's therapy, resource, evaluation, and assessment tool (TREAT) registry update has added to these concerns by demonstrating an association of opiate use with an increased risk of infection and death in CD. While the association is clear, the relationship of opiates to these negativ...

Journal: :Biochemical Society transactions 1983
N J Cuthbert D L Francis H O Collier

65 The decreased sensitivity to clonidine would appear to be an important and reversible sign of withdrawal in the guinea-pig ileum. Such interactions between opiate receptors and a-adren-ergic receptors do not appear to occur in the mouse vas deferens (Gillan et al., 1979). However, vasa deferentia from rats treated chronically with clonidine showed lower sensitivity to the inhibitory effects ...

2010
Rosie Cornish John Macleod John Strang Peter Vickerman Matt Hickman

OBJECTIVE To investigate the effect of opiate substitution treatment at the beginning and end of treatment and according to duration of treatment. DESIGN Prospective cohort study. Setting UK General Practice Research Database. PARTICIPANTS Primary care patients with a diagnosis of substance misuse prescribed methadone or buprenorphine during 1990-2005. 5577 patients with 267 003 prescriptio...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1986
W S Willcockson J Kim H K Shin J M Chung W D Willis

The effects of iontophoretically applied opiates were tested on 24 spinothalamic tract cells in 12 anesthetized monkeys. The drugs used were chosen because of their agonist actions on different classes of opiate receptors (mu, morphine; kappa, dynorphin; delta, methionine enkephalinamide; sigma, N-allylnormetazocine or SKF 10047 and phencyclidine). The actions of the opiate drugs were generally...

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