Whether pulmonary arterial hypertension (PAH) is reversible in congenital heart disease (CHD) is important for the operability of CHD. However, little is known about that. Our research was aimed at exploring novel biomarkers and targets in the reversibility of CHD-PAH. CHD-PAH patients diagnosed with right heart catheterization (RHC) were enrolled (n = 14). Lung biopsy was performed during the ...

The objective in this work is to develop a machine learning-based framework for process operability using surrogate responses based on Kriging (also known as Gaussian Process Regression). Currently, the available approaches nonlinear systems are limited by problem dimensionality that they can address, not being computationally tractable high-dimensional systems. proposed approach will use Krigi...

The seismic performance of nuclear power valve is one the important indexes to measure its safety and reliability. analysis, thermal stress calculation, fatigue analysis experimental verification a class I three-way are carried out. Firstly, natural frequency, strain high temperature pressure analyzed. Secondly, calculation methods put forward. Finally, through frequency sweep test valve, opera...

HAZOP (Hazard and Operability) is a preliminary and systematic approach for identifying hazards and suggesting hazard mitigation measures in a process facility. A knowledge-based expert system, ExpHAZOP, has been developed to automate the manual HAZOP analysis and accelerate the process. ExpHAZOP is comprised of a graphical user interface (GUI), a knowledge-base and an inference engine. One of ...

The plant design and control tasks are usually carried out sequentially. Initially the plant is designed and then the control structure is determined as a function of the design. Such a formulation neglects the coupling between design and control. This may lead to processes where a suitable control scheme cannot be synthesized for a given design. Even if a control scheme can be generated, it ha...