objective: dermatophytosis is one of the most common pandemic fungal infections that is a major health problem in cities and villages. this study aims to evaluate pcr sensitivity and accuracy in the detection of nail dermatophytosis compared to conventional direct and culture detection methods, and performs an assessment of trichophyton rubrum in patients suspected of having nail dermatophytosi...

background: although  candida albicans  remains the most common fungal isolate from clinical specimens, many studies have detected a shift towards non-albicans  candida species. despite worrying clinical pictures associated with latter species , there is little information regarding its susceptibility patterns against currently available antifungal agents, with only a small number of strains ha...

background and purpose: candida species are the most opportunistic fungi affecting the nails and resulting in onychomycosis. in this study, we identified and evaluated in-vitro susceptibility of the recovered isolates against fluconazole (flc), voriconazole (vrc), and clotrimazole (clt) using the clinical and laboratory standards institute (clsi) m27-a3 document. materials and methods: from pat...

Onychomycosis is a common nail infection. Terbinafine-resistant dermatophyte infections pose an emerging global public health concern, but few cases have been described in the United States. We retrospectively reviewed and characterized clinical, histopathological, mycological features of patients with mycologically confirmed onychomycosis who failed oral terbinafine treatment for at U.S. acade...

Until a few years ago, griseofulvin and ketoconazole were the only 2 oral agents available for the treatment of dermatophyte onychomycosis of the toenails. With the availability of the newer antifungal agents, such as itraconazole, terbinafine and fluconazole, the armamentarium of drugs available to treat onychomycosis has expanded. The objective of this study was to determine the relative cost...

Background: At present time, the diagnosis of onychomycosis is based on clinical signs, direct exam and fungal culture, whereas Pathologic methods have shown to be more sensitive than other methods. Objective: Evaluation of pathologic methods in the diagnosis of onychomycosis in comparison to direct smear and culture. Patients and Methods: A nail sample was cut form 96 suspected onychomycosis p...

Onychomatricoma is a rare tumour of the nail matrix with peculiar clinical and histological features and electron microscopic findings. We report on 5 cases with appearances which were misleading. Three presented as longitudinal melanonychia, a previously unreported observation. One case had the appearance of a cutaneous horn. In 3 of the 5 cases the tumour was associated with an onychomycosis ...

In considering therapy for onychomycosis, the most important factor to take into account is patient selection rather than treatment selection. Patients should be screened and evaluated for the extent of nail involvement, the amount of subungual debris, the degree of dystrophy, their ability and willingness to follow the regimen, and whether comorbidities are present that may affect the efficacy...

Introduction: The clinical pictures of nail dystrophies caused by different fungi are seldom diagnostic. Mycological confirmation with appropriate diagnostic techniques including direct microscopy and fungal culture is important to ensure correct diagnosis and treatment. Microscopy can be performed using potassium hydroxide (KOH) mount and histological evaluation of nail plate specimens with th...

This paper presents for the first time the isolation of Fusarium oxysporum from the toenails of a man from Tehran. The fungus was demonstrated in KOH mounts and was isolated repeatedly from his nail scrapings over a 2 month period. Published reviews on onychomycosis in Iran have not revealed any cases of white superficial onychomycosis due to Fusarium oxysporum to date