A one-pot chemoenzymatic sequential cascade for the synthesis of chiral amines from alkynes was developed. In this integrated approach, just ppm amounts gold catalysts enabled conversion to ketones (>99%) after which a transaminase used catalyze production biologically valuable in good yield (up 99%) and enantiomeric excess (>99%). preparative scale (S)-methylbenzylamine (S)-4-methoxy-methylben...