Erythroid colonies from cord blood in which both late (CFU-E) and early (BFU-E) erythroid precursors are present, were grown by the plasma clot technique. Hemoglobin (Hb) synthesis was studied and compared in fresh reticulocytes. 7-day-old colonies. and 14-day-old colonies. In the 8 cases studied, the proportion of HbA synthesis progresssively increased from circulating reticulocytes to 7-day-o...

Children are vulnerable to environmental mutagens, and the developing germline could also be affected. However, little is known about whether exposure to environmental mutagens in childhood will result in increased germline mutations in subsequent adult life. In the present study, male transgenic lacI mice at different ages (7, 25 and 60 days old) were treated with a known environmental mutagen...

Facial, olfactory, and vocal cues may advertise women's fertility. However, most of the evidence for this proposal has come from studies of changes in young adult women's attractiveness over the menstrual cycle. By contrast with this emphasis on changes in attractiveness over the menstrual cycle, possible changes in women's attractiveness over their lifespan have received little attention. The ...

OBJECTIVE To compare the effectiveness of no exercise with prehabilitation (exercise before hindlimb unweighting [HLU]) versus rehabilitation (exercise given after HLU) on gait function and skeletal muscle mass and force. DESIGN Randomized controlled trial. SETTING Animal laboratory. ANIMALS Male-specific, pathogen-free Fisher344/Brown Norway rats (N=149). Groups consisted of adult and ol...

The lymphocytic growth hormone (GH) and nitric oxide (NO) levels were studied among three different age groups of cattle viz. cyclic adult cows (3-8 years of age), young female calves (2 weeks old) and growing female calves (6 months old). The effects of leptin, sodium nitroprusside (SNP) and N-nitro-L-arginine methyl ester (L-NAME) on the secretion of lymphocytic GH and NO were also studied. L...

Results of neural grafting to excitotoxic and ischemic lesions of the adult rat hippocampus is reviewed with particular emphasis on the exchange of host-transplant nerve connections. Based on observations obtained by a variety of tracing techniques about 6 weeks after--(i) grafting of pieces of neonatal fascia dentata to one week old ibotenic acid lesions of the adult rat fascia dentata, (ii) g...

Early life experiences may affect adult learning ability. In two experiments we tested the effect of early learning failure on adult performance in Wistar rats. In the first experiment 17-day-old rats (PN17), but not 25-day-old rats (PN25), trained in a hidden platform water maze task showed deficits in tone-shock avoidance learning when they were 3-months-old. The second experiment, which incl...

Adult intussusception generally has a distinct pathological cause as lead point. Inflammatory fibroid polyp (IFP) is rare non-neoplastic submucosal lesion, furthermore, that causing ileocolic in an adult even rarer. Here we present case of 32-year-old female who presented with complaints intermittent colicky pain associated vomiting for 3 days. Computer tomography (CT) showed bowel obstruction ...

M.R. VASKO, L.E. DOMINO and E.F. DOMINO, Differential effects of d-amphetamine on brain acetylcholine in young, adult and geriatric rats, European J. Pharmacol. 27 (1974) 145-147. Varying doses of d-amphetamine were given i.p. to young (28 day old), adult (approximately 90 day old), and geriatric rats (approximately 2 years old). 30 min after injection, rats were sacrificed and ACH extracted an...