Although retinoic acid (RA) teratogenicity has been investigated for decades, the mechanisms underlying RA-induced outflow tract (OFT) malformations are not understood. Here, we show zebrafish embryos deficient for Cyp26a1 and Cyp26c1 enzymes, which promote RA degradation, have OFT defects resulting from two mechanisms: first, a failure of second heart field (SHF) progenitors to join the OFT, i...

Starke Müdigkeit ist eine der wichtigsten krankheitsbegleitenden Folgen von rheumatoider Arthritis (RA). Obwohl als multidimensionales Phänomen betrachtet wird, das zahlreichen Faktoren beeinflusst bisher unklar, wie diese in Zusammenhang mit RA steht. Holten et al. erforschten die longitudinale Prävalenz bei Patienten früher und ermittelten Prädiktoren.

poisonin-u b.v neurotoxic organo phproblem in iranosphorusproducts is frequentreanimation oft hesc patients depends on the followin g: i - to bcgin rea nimation ra pid ly. 2 - usage ofatropine and special a nticholisterasics antidotes. in case of need for surgical intervention. - the use of succinv. lcholin isprohibited and other muscle relexants should be used with most care.

Laboratory animals often develop abnormal repetitive (stereotypic) behaviour that can influence both physiology and behavioural test results. Such behaviours usually in suboptimal environment increase over time. To explore the development of stereotypic forms activity night home-cage laboratory mice was analysed collated with open field (OFT), hole-board (HBT) tail suspension (TST) tests twice ...

Objective: The purpose of this study was to determine the activity and optimal dose Muntingia calabura L. ethanol extract as an antidepressant using Forced Swimming Test (FST), Tail Suspensions (TST), Open Field (OFT).
 Methods: Twenty-five male Swiss-Webster mice were randomly divided into five groups. Group 1 a control group, got vehicle (1% w/v CMC). As positive control, group 2 0.052 m...

The study of partition relations dates back to 1930, when F. P. Ramsey [50] proved his oft-cited theorem.