نتایج جستجو برای: oesophageal adenocarcinoma
تعداد نتایج: 69132 فیلتر نتایج به سال:
the present study was performed to examine the sequential process of the development of Barrett's oesophagus (BE) and oesophageal adenocarcinoma (ADC) induced by duodeno-oesophageal reflux (DER) in rats. Total gastrectomy was performed in male Wistar rats weighing approximately 250 g followed by reconstruction with oesophago-jejunostomy, which causes unavoidable DER without exposure to exogenou...
BACKGROUND Adenocarcinomas of the oesophagus and proximal stomach are the most rapidly increasing malignancies in some countries; however, there are no comparative studies on global disease incidence, and the relationships between these two malignancies are undefined. METHODS We evaluated the cumulative rates and age-specific incidence rates per 100 000 population for adenocarcinomas of the o...
BACKGROUND Based on reported familial patterns, inheritance of a predisposition of developing Barrett's oesesophagus (BO) and oesophageal adenocarcinoma (OAC) likely follows an autosomal dominant model of most inherited cancer syndromes. oesophagus (BO) and oesophageal adenocarcinoma (OAC) likely follows an autosomal dominant model of most inherited cancer syndromes. AIMS We analysed the phen...
BACKGROUND Resectable oesophageal cancer is often treated with surgery alone or with preoperative (neoadjuvant) chemoradiotherapy or chemotherapy. We aimed to clarify the benefits of neoadjuvant chemoradiotherapy or chemotherapy versus surgery alone by a meta-analysis of randomised trial data. METHODS Eligible trials were identified first from earlier published meta-analyses and systematic re...
BACKGROUND Proliferating and tumour cells express the glycolytic isoenzyme, pyruvate kinase type M2 (M2-PK). In tumours cells, M2-PK usually exists in dimeric form (tumour M2-PK), causing the accumulation of glycolytic phosphometabolites, which allows cells to invade areas with low oxygen and glucose concentrations. AIMS To investigate the expression of tumour M2-PK during the metaplasia-dysp...
Abstract Background Oesophageal adenocarcinoma (OAC) is of increasing global concern due to incidence, lack effective treatments, and poor prognosis. Therapeutic target discovery clinical trials have been hindered by the heterogeneity disease, dominance large-scale genomic rearrangements, driver mutations. We profiled small-molecule compounds using an innovative high content imaging assay in a ...
Abstract Background Perioperative chemotherapy is widely used in the treatment of oesophageal cancer with substantial survival benefit over surgery alone. However, postoperative part these regimens given less than half cases, reflecting uncertainty about its benefit. This study estimates effect after for using a large population-based dataset and modern statistical methods. Methods Patients ade...
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